Su Cheng-Fu, Jiang Li, Zhang Xiao-Wen, Iyaswamy Ashok, Li Min
College of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, China.
Mr. & Mrs. Ko Chi-Ming Centre for Parkinson's Disease Research, School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Front Pharmacol. 2021 Apr 22;12:644219. doi: 10.3389/fphar.2021.644219. eCollection 2021.
Parkinson's disease (PD) is a common neurodegenerative disease featured by progressive degeneration of nigrostriatal dopaminergic neurons (DA) accompanied with motor function impairment. Accumulating evidence has demonstrated that natural compounds from herbs have potent anti-PD efficacy in PD models. Among those compounds, resveratrol, a polyphenol found in many common plants and fruits, is more effective against PD. Resveratrol has displayed a potent neuroprotective efficacy in several PD animal models. However, there is still no systematic analysis of the quality of methodological design of these studies, nor of their results. In this review, we retrieved and analyzed 18 studies describing the therapeutic effect of resveratrol on PD animal models. There are 5 main kinds of PD rodent models involved in the 18 articles, including chemical-induced (MPTP, rotenone, 6-OHDA, paraquat, and maneb) and transgenic PD models. The neuroprotective mechanisms of resveratrol were mainly concentrated on the antioxidation, anti-inflammation, ameliorating mitochondrial dysfunction, and motor function. We discussed the disadvantages of different PD animal models, and we used meta-analysis approach to evaluate the results of the selected studies and used SYRCLE's risk of bias tool to evaluate the methodological quality. Our analytical approach minimized the bias of different studies. We have also summarized the pharmacological mechanisms of resveratrol on PD models as reported by the researchers. The results of this study support the notion that resveratrol has significant neuroprotective effects on different PD models quantified using qualitative and quantitative methods. The collective information in our review can guide researchers to further plan their future experiments without any hassle regarding preclinical and clinical studies. In addition, this collective assessment of animal studies can provide a qualitative analysis of different PD animal models, either to guide further testing of these models or to avoid unnecessary duplication in their future research.
帕金森病（PD）是一种常见的神经退行性疾病，其特征是黑质纹状体多巴胺能神经元（DA）进行性退化，并伴有运动功能障碍。越来越多的证据表明，草药中的天然化合物在PD模型中具有强大的抗PD功效。在这些化合物中，白藜芦醇是一种存在于许多常见植物和水果中的多酚，对PD更有效。白藜芦醇在几种PD动物模型中显示出强大的神经保护功效。然而，对于这些研究的方法设计质量及其结果仍没有系统的分析。在本综述中我们检索并分析了18项描述白藜芦醇对PD动物模型治疗效果的研究。这18篇文章涉及5种主要的PD啮齿动物模型，包括化学诱导（MPTP、鱼藤酮、6-羟基多巴胺、百草枯和代森锰）和转基因PD模型。白藜芦醇的神经保护机制主要集中在抗氧化、抗炎、改善线粒体功能障碍和运动功能方面。我们讨论了不同PD动物模型的缺点，并使用荟萃分析方法评估所选研究的结果，使用SYRCLE的偏倚风险工具评估方法学质量。我们的分析方法将不同研究的偏倚降至最低。我们还总结了研究人员报道的白藜芦醇对PD模型的药理机制。本研究结果支持这样一种观点，即白藜芦醇对使用定性和定量方法量化的不同PD模型具有显著的神经保护作用。我们综述中的这些综合信息可以指导研究人员在没有任何临床前和临床研究麻烦的情况下进一步规划他们未来的实验。此外，这种对动物研究的综合评估可以对不同的PD动物模型进行定性分析，以指导对这些模型的进一步测试，或避免在其未来研究中出现不必要的重复。
