Programa de Pós-Graduação em Ciências Fisiológicas, Instituto de Ciências Biológicas, Universidade Federal do Rio Grande-FURG, Rio Grande, RS, Brazil.
Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina, Universidade Federal do Rio Grande-FURG, Rio Grande, RS, Brazil.
Neurotox Res. 2022 Feb;40(1):319-345. doi: 10.1007/s12640-021-00450-x. Epub 2022 Jan 11.
Parkinson's disease (PD) is currently the second most common neurodegenerative disease, being characterized by motor and non-motor symptoms. The therapeutic options available for its treatment are limited, do not slow the progression of the disease, and have serious side effects. For this reason, many studies have sought to find compounds with neuroprotective properties that bring additional benefits to current therapy. In this context, resveratrol is a phenolic compound, found in many plant species, capable of crossing the blood-brain barrier and having multiple biological properties. Experimental studies in vitro and in vivo have shown that it can prevent or slow the progression of a variety of diseases, including PD. In this systematic review, we summarize the effects of resveratrol in experimental in vivo and in vitro models of PD and discuss the molecular mechanisms involved in its action. The bibliographic search was performed in the databases of PubMed, Web of Science, SciELO, and Google Scholar, and based on the inclusion criteria, 41 articles were selected and discussed. Most of the included studies have demonstrated neuroprotective effects of resveratrol. In general, resveratrol prevented behavioral and/or neurological disorders, improved antioxidant defenses, reduced neuroinflammatory processes, and inhibited apoptosis. In summary, this systematic review offers important scientific evidence of neuroprotective effects of resveratrol in PD and also provide valuable information about its mechanism of action that can support future clinical studies.
帕金森病（PD）是目前第二常见的神经退行性疾病，其特征为运动和非运动症状。目前可用于治疗的治疗方法有限，不能减缓疾病的进展，且具有严重的副作用。出于这个原因，许多研究都试图寻找具有神经保护特性的化合物，为当前的治疗带来额外的益处。在这种情况下，白藜芦醇是一种酚类化合物，存在于许多植物物种中，能够穿过血脑屏障并具有多种生物学特性。体外和体内的实验研究表明，它可以预防或减缓多种疾病的进展，包括 PD。在本系统评价中，我们总结了白藜芦醇在 PD 的体内和体外实验模型中的作用，并讨论了其作用涉及的分子机制。文献检索在 PubMed、Web of Science、SciELO 和 Google Scholar 数据库中进行，并根据纳入标准选择和讨论了 41 篇文章。大多数纳入的研究都证明了白藜芦醇的神经保护作用。总的来说，白藜芦醇预防了行为和/或神经障碍，改善了抗氧化防御，减少了神经炎症过程，并抑制了细胞凋亡。总之，本系统评价为 PD 中白藜芦醇的神经保护作用提供了重要的科学证据，并提供了有关其作用机制的有价值信息，这可以为未来的临床研究提供支持。
