Utpal Biswajit Kumar, Mokhfi Fatima Zohra, Zehravi Mehrukh, Sweilam Sherouk Hussein, Gupta Jeetendra Kumar, Kareemulla Shaik, C Ronald Darwin, Rao A Anka, Kumar Voleti Vijaya, Krosuri Pavankumar, Prasad Dharani, Khan Sharukh L, Roy Sajib Chandra, Rab Safia Obaidur, Alshehri Mohammed Ali, Emran Talha Bin
Department of Pharmacy, Faculty of Health and Life Sciences, Daffodil International University, Dhaka, 1207, Bangladesh.
Laboratory of AgroBiotechnology and Nutrition in Semi Arid Zones, Faculty of Nature and Life Sciences, University of Ibn Khaldoun, Tiaret, Algeria.
Mol Neurobiol. 2025 May;62(5):5579-5608. doi: 10.1007/s12035-024-04608-4. Epub 2024 Nov 23.
Neurological diseases (NDs), including neurodegenerative disorders and acute injuries, are a significant global health concern. The PI3K/Akt/mTOR pathway, a crucial signaling cascade, is responsible for the survival of cells, proliferation, and metabolism. Dysregulation of this pathway has been linked to neurological conditions, indicating its potential as a vital target for therapeutic approaches. Resveratrol (RSV), a natural compound found in berries, peanuts, and red grapes, has antioxidant, anti-cancer, and anti-inflammatory effects. Its ability to modulate the PI3K/Akt/mTOR pathway has been interesting in NDs. Studies have shown that RSV can activate the PI3K/Akt pathway, promoting cell survival and inhibiting apoptosis of neuronal cells. Its impact on mTOR, a downstream effector of Akt, further contributes to its neuroprotective effects. RSV's ability to restore autophagic flux presents a promising avenue for therapeutic intervention. Its anti-inflammatory properties suppress inflammatory responses by inhibiting key signaling molecules within the pathway. Additionally, RSV's role in enhancing mitochondrial function contributes to its neuroprotective profile. This study highlights RSV's potential as a multifaceted therapeutic agent in NDs, specifically by PI3K/Akt/mTOR pathway modulation. Additional investigation is required to optimize its therapeutic capacity in diverse neurological conditions.
神经疾病（NDs），包括神经退行性疾病和急性损伤，是全球重大的健康问题。PI3K/Akt/mTOR信号通路作为一个关键的信号级联反应，负责细胞的存活、增殖和代谢。该信号通路的失调与神经疾病有关，这表明它有潜力成为治疗方法的重要靶点。白藜芦醇（RSV）是一种存在于浆果、花生和红葡萄中的天然化合物，具有抗氧化、抗癌和抗炎作用。它调节PI3K/Akt/mTOR信号通路的能力在神经疾病中备受关注。研究表明，RSV可以激活PI3K/Akt信号通路，促进细胞存活并抑制神经元细胞的凋亡。它对Akt的下游效应器mTOR的影响，进一步增强了其神经保护作用。RSV恢复自噬通量的能力为治疗干预提供了一条有前景的途径。其抗炎特性通过抑制该信号通路中的关键信号分子来抑制炎症反应。此外，RSV在增强线粒体功能方面的作用也有助于其神经保护作用。本研究强调了RSV作为神经疾病多方面治疗剂的潜力，特别是通过调节PI3K/Akt/mTOR信号通路。需要进一步研究以优化其在各种神经疾病中的治疗能力。
