Sadeghi-Haddad-Zavareh Mahmoud, Bayani Masomeh, Shokri Mehran, Ebrahimpour Soheil, Babazadeh Arefeh, Mehraeen Rahele, Moudi Emadoddin, Rostami Ali, Barary Mohammad, Hosseini Akram, Bijani Ali, Javanian Mostafa
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Department of Radiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
Interdiscip Perspect Infect Dis. 2021 Apr 23;2021:5557582. doi: 10.1155/2021/5557582. eCollection 2021.
While some biomolecules have been explored to identify potential biomarkers for the prognosis of COVID-19 patients, there is no reliable prognostic indicator of the disease progression and severity. We aimed to evaluate the ability of the C-reactive protein (CRP) to predict COVID-19 infection outcome. This retrospective study was conducted on 429 patients diagnosed with COVID-19 between March 30, 2020, and April 30, 2020. The study population was divided into severe ( = 175) and nonsevere cases ( = 254). Data on demographic characteristics, clinical features, and laboratory findings on admission were collected. The proportion of patients with increased CRP levels was significantly higher in severe cases than in nonsevere patients. Analysis of the receiver operating characteristic (ROC) curve found that CRP could be used as an independent factor in predicting the severity of COVID-19. Also, patients with CRP >64.75 mg/L were more likely to have severe complications. In conclusion, CRP serum levels can predict the severity and progression of illness in patients with COVID-19.
虽然已经探索了一些生物分子来确定COVID-19患者预后的潜在生物标志物，但对于该疾病的进展和严重程度，尚无可靠的预后指标。我们旨在评估C反应蛋白（CRP）预测COVID-19感染结果的能力。这项回顾性研究对2020年3月30日至2020年4月30日期间确诊为COVID-19的429例患者进行。研究人群分为重症（n = 175）和非重症病例（n = 254）。收集了入院时的人口统计学特征、临床特征和实验室检查结果数据。重症病例中CRP水平升高的患者比例显著高于非重症患者。对受试者工作特征（ROC）曲线的分析发现，CRP可作为预测COVID-19严重程度的独立因素。此外，CRP>64.75mg/L的患者更有可能出现严重并发症。总之，CRP血清水平可以预测COVID-19患者疾病的严重程度和进展。
