Department of Pharmacy, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai Institute of Cardiovascular Disease, Shanghai, China.
Dis Markers. 2021 Apr 21;2021:6653501. doi: 10.1155/2021/6653501. eCollection 2021.
Progranulin (PGRN) and its potential receptor Eph-receptor tyrosine kinase-type A2 (EphA2) are inflammation-related molecules that present on the atherosclerotic plaques. However, the roles of circulating PGRN and EphA2 in coronary artery disease (CAD) remain unclear.
To study the clinical significance of circulating PGRN and EphA2 levels in Chinese patients undergoing coronary angiography.
Levels of circulating EphA2 fragments and PGRN were examined in 201 consecutive individuals who underwent coronary angiography for suspected CAD in our center from Jan 2020 to Oct 2020. Demographic characteristics, results of biochemical and auxiliary examinations, and other relevant information were collected. The coronary atheroma burden was quantified by the Gensini score and the existence of chronic total occlusion (CTO). Univariate analysis and multivariate logistic regression analysis were used to analyze the risk factors for acute coronary syndrome (ACS). In patients with ACS and SAP, a receiver operating characteristic (ROC) curve was generated to detect the accuracy and discriminative ability of levels of EphA2 and PGRN, the Gensini score, and cardiac injury biomarkers as surrogate endpoints for CTO.
Circulating EphA2 levels were significantly higher in patients with ACS than in subjects with stable angina pectoris (SAP) or control subjects ( < 0.001). A positive linear correlation was verified between EphA2 levels and the Gensini score ( = 0.306, < 0.001), and negative correlation was detected with the left ventricular ejection fraction (LVEF) ( = -0.405, < 0.001). Both PGRN and EphA2 were positively associated with cardiac injury biomarkers (i.e., NT-proBNP, cTnT, and hs-CRP) ( < 0.05). The area under the ROC curve of PGRN and EphA2 was 0.604 and 0.686, respectively ( < 0.01).
Higher circulating EphA2 and PGRN levels were detected in patients with ACS than in patients with SAP. Circulating EphA2 and PGRN levels might be diagnostic factors for predicting the atheroma burden in patients with CAD.
颗粒蛋白前体（PGRN）及其潜在受体 Eph 受体酪氨酸激酶 A2（EphA2）是与动脉粥样硬化斑块相关的炎症相关分子。然而，循环 PGRN 和 EphA2 在冠心病（CAD）中的作用尚不清楚。
研究中国行冠状动脉造影术患者循环 PGRN 和 EphA2 水平的临床意义。
2020 年 1 月至 10 月，我们中心对 201 例疑似 CAD 行冠状动脉造影术的患者进行了循环 EphA2 片段和 PGRN 水平检测。收集了人口统计学特征、生化和辅助检查结果及其他相关信息。采用 Gensini 评分和慢性完全闭塞（CTO）来量化冠状动脉粥样硬化斑块负担。采用单因素分析和多因素 logistic 回归分析来分析急性冠状动脉综合征（ACS）的危险因素。在 ACS 和 SAP 患者中，生成了受试者工作特征（ROC）曲线，以检测 EphA2 和 PGRN 水平、Gensini 评分和心脏损伤生物标志物作为 CTO 替代终点的准确性和区分能力。
ACS 患者的循环 EphA2 水平明显高于稳定型心绞痛（SAP）患者或对照组（ < 0.001）。EphA2 水平与 Gensini 评分呈正相关（ = 0.306， < 0.001），与左心室射血分数（LVEF）呈负相关（ = -0.405， < 0.001）。PGRN 和 EphA2 均与心脏损伤生物标志物（即 NT-proBNP、cTnT 和 hs-CRP）呈正相关（ < 0.05）。PGRN 和 EphA2 的 ROC 曲线下面积分别为 0.604 和 0.686（ < 0.01）。
ACS 患者的循环 EphA2 和 PGRN 水平高于 SAP 患者。循环 EphA2 和 PGRN 水平可能是预测 CAD 患者动脉粥样硬化斑块负担的诊断因素。
