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一名儿科患者出现长时间癫痫发作,随后发生严重高磷血症和低钙血症。

Prolonged Seizure Activity Followed by Severe Hyperphosphatemia and Hypocalcemia in a Pediatric Patient.

作者信息

Coriell Megan B, Van Hersh Andrew T, Shah Siddharth

机构信息

Pediatric Endocrinology, University of Louisville School of Medicine, Louisville, USA.

Pediatrics, University of Louisville School of Medicine, Louisville, USA.

出版信息

Cureus. 2021 Apr 7;13(4):e14338. doi: 10.7759/cureus.14338.

DOI:10.7759/cureus.14338
PMID:33968541
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8103793/
Abstract

Seizures secondary to hypocalcemia have been well documented and studied. There are various causes of hypocalcemia described in the literature, but a prolonged seizure episode leading to cell lysis, severe hyperphosphatemia, and hypocalcemia is rarely reported. We present the case of a 3-year-old male with severe hyperphosphatemia and hypocalcemia secondary to the likely presence of cell lysis from prolonged seizure activity. Our case illustrates the importance of a thorough evaluation of the possible differentials of hypocalcemia and hyperphosphatemia in a challenging presentation.

摘要

低钙血症继发的癫痫发作已有充分的文献记载和研究。文献中描述了低钙血症的各种病因,但因长时间癫痫发作导致细胞溶解、严重高磷血症和低钙血症的情况鲜有报道。我们报告了一例3岁男性患儿,因长时间癫痫活动可能导致细胞溶解继发严重高磷血症和低钙血症。我们的病例说明了在具有挑战性的病例中对低钙血症和高磷血症可能的鉴别诊断进行全面评估的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d91c/8103793/029ddc9de749/cureus-0013-00000014338-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d91c/8103793/029ddc9de749/cureus-0013-00000014338-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d91c/8103793/029ddc9de749/cureus-0013-00000014338-i01.jpg

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本文引用的文献

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Idiopathic Primary Hypoparathyroidism Presenting as Focal Seizures in a Neonate: A Rare Occurrence.以局灶性癫痫发作为表现的新生儿特发性原发性甲状旁腺功能减退症:罕见病例
Cureus. 2020 Sep 10;12(9):e10348. doi: 10.7759/cureus.10348.
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Diagnostic Value of Serum Procalcitonin in Patients with Convulsion in Emergency Department, an Observational Study.血清降钙素原在急诊科惊厥患者中的诊断价值:一项观察性研究
Antibiotics (Basel). 2020 Oct 8;9(10):683. doi: 10.3390/antibiotics9100683.
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Severe Hypocalcemia and Extreme Elevation of Serum Creatinkinase in a 16-Year Old Boy with Pseudohypoparathyroidism Type Ib.
一名患有Ib型假性甲状旁腺功能减退症的16岁男孩出现严重低钙血症和血清肌酸激酶极度升高
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Diagnosis and management of pseudohypoparathyroidism and related disorders: first international Consensus Statement.假性甲状旁腺功能减退症及相关疾病的诊断与管理:第一份国际共识声明。
Nat Rev Endocrinol. 2018 Aug;14(8):476-500. doi: 10.1038/s41574-018-0042-0.
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Rhabdomyolysis with different etiologies in childhood.儿童期不同病因的横纹肌溶解症。
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Efficacy and safety of sevelamer carbonate in hyperphosphatemic pediatric patients with chronic kidney disease.碳酸司维拉姆治疗慢性肾脏病高磷血症儿童患者的疗效和安全性。
Pediatr Nephrol. 2018 Feb;33(2):325-333. doi: 10.1007/s00467-017-3787-0. Epub 2017 Sep 12.
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Afebrile Seizures as Initial Symptom of Hypocalcemia Secondary to Hypoparathyroidism.无热惊厥作为甲状旁腺功能减退继发低钙血症的首发症状
J Neurosci Rural Pract. 2016 Dec;7(Suppl 1):S117-S119. doi: 10.4103/0976-3147.196457.
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J Family Med Prim Care. 2013 Jan;2(1):86-7. doi: 10.4103/2249-4863.109962.
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