Almas Talal, Ullah Irfan, Kaneez Mehwish, Ehtesham Maryam, Rauf Shahzad
Internal Medicine, Royal College of Surgeons in Ireland, Dublin, IRL.
Researcher, Undergraduate Research Organisation, Dhaka, BGD.
Cureus. 2020 Sep 10;12(9):e10348. doi: 10.7759/cureus.10348.
Focal seizures in neonates presenting to the emergency department can be potentially dangerous and life-threatening. Hypoparathyroidism is an exceedingly rare but treatable cause of focal neonatal seizures. Due to its weak association with neonatal seizures, hypoparathyroidism often remains undetected as a potential cause. We hereby elucidate a rare case of idiopathic hypoparathyroidism presenting as right-sided focal seizures in a 12-day-old female neonate with an uneventful birth history. Despite the administration of antibiotics and phenobarbitone, the seizures remained unabated. Laboratory workup revealed the diagnosis of late-onset hypocalcemia with severe hypoparathyroidism. The patient was subsequently treated with calcium supplements and alfacalcidol. Thereafter, the frequency of seizures gradually decreased and the same treatment regimen was continued until the patient was seizure-free. The patient continues to do well to date with complete remission of his clinical symptoms.
到急诊科就诊的新生儿局灶性癫痫发作可能具有潜在危险性，甚至危及生命。甲状旁腺功能减退是新生儿局灶性癫痫发作极为罕见但可治疗的病因。由于其与新生儿癫痫发作的关联较弱，甲状旁腺功能减退常未被发现是潜在病因。在此，我们阐明一例罕见的特发性甲状旁腺功能减退病例，该病例表现为一名出生史正常的12日龄女婴出现右侧局灶性癫痫发作。尽管使用了抗生素和苯巴比妥，癫痫发作仍未缓解。实验室检查确诊为迟发性低钙血症伴严重甲状旁腺功能减退。该患者随后接受了钙剂和阿法骨化醇治疗。此后，癫痫发作频率逐渐降低，并继续采用相同的治疗方案，直至患者无癫痫发作。该患者至今情况良好，临床症状完全缓解。
