Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain.
Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain.
Front Cell Infect Microbiol. 2021 Apr 22;11:639573. doi: 10.3389/fcimb.2021.639573. eCollection 2021.
Soil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the most important neglected tropical diseases in terms of morbidity. Due to the difficulty in studying STH human infections, rodent models have become increasingly used, mainly because of their similarities in life cycle. and have been proven appropriate and low maintenance models for the study of ascariasis and trichuriasis. In the case of hookworms, despite most of the murine models do not fully reproduce the life cycle of , their proteomic similarity makes them highly suitable for the development of novel vaccine candidates and for the study of hookworm biological features. Furthermore, these models have been helpful in elucidating some basic aspects of our immune system, and are currently being used by numerous researchers to develop novel molecules with immunomodulatory proteins. Herein we review the similarities in the proteomic composition between , and and their respective human counterpart with a focus on the vaccine candidates and immunomodulatory proteins being currently studied.
土壤传播性蠕虫（STH）影响着全球数亿人，它们是发病率方面最重要的被忽视热带病之一。由于研究人类 STH 感染的难度，啮齿动物模型越来越多地被使用，主要是因为它们在生命周期方面的相似性。在蛔虫和鞭虫感染方面， 和 已被证明是合适且低维护的模型，可用于研究蛔虫病和鞭虫病。在钩虫方面，尽管大多数鼠类模型不能完全复制 的生命周期，但它们蛋白质组的相似性使它们非常适合开发新型疫苗候选物，并研究钩虫的生物学特征。此外，这些模型有助于阐明我们免疫系统的一些基本方面，目前许多研究人员正在利用它们来开发具有免疫调节蛋白的新型分子。本文综述了 、 和 与各自人类对应物之间的蛋白质组组成的相似性，重点介绍了当前正在研究的疫苗候选物和免疫调节蛋白。
