Hrudka Jan, Švadlenková Ivana
Charles University, 3rd Faculty of Medicine, University Hospital Královské Vinohrady, Department of Pathology, Prague, Czech Republic.
Charles University, 3rd Faculty of Medicine, University Hospital Královské Vinohrady, Department of General Surgery, Prague, Czech Republic.
Autops Case Rep. 2021 Mar 26;11:e2021255. doi: 10.4322/acr.2021.255.
Undifferentiated or anaplastic thyroid carcinoma (ATC) is rare and one of the most aggressive human malignancies. The tumor is usually voluminous and fast-growing and mostly affects older women. The most common sites of distant metastases are the lungs, brain, and bones. Herein, we describe the case of a 66-year-old woman with a history of bilateral breast carcinoma and ATC, who presented with an acute abdomen and subsequently died. At autopsy, an isolated metastasis of ATC in the small intestine leading to bowel perforation was found. Moreover, there was adenocarcinoma in the descending colon. The review of extra-abdominal malignancies metastasizing to bowel and coincidence of breast and thyroid carcinoma is included.
未分化或间变性甲状腺癌（ATC）较为罕见，是人类最具侵袭性的恶性肿瘤之一。该肿瘤通常体积较大且生长迅速，主要影响老年女性。远处转移最常见的部位是肺、脑和骨骼。在此，我们描述了一例66岁女性病例，该患者有双侧乳腺癌和ATC病史，因急腹症就诊，随后死亡。尸检发现小肠有ATC孤立转移灶，导致肠穿孔。此外，降结肠存在腺癌。本文还包括对转移至肠道的腹外恶性肿瘤以及乳腺癌和甲状腺癌并存情况的综述。
