Cartillone Mariacristina, Sarvà Iacopo, Mazzone Chiara, Litrico Giorgia, Picardo Maria Carolina, Latteri Francesco Saverio, La Greca Gaetano
General Surgery, Cannizzaro Hospital, Catania, Italy.
Int J Colorectal Dis. 2025 Jan 22;40(1):23. doi: 10.1007/s00384-025-04804-1.
In this article, we aim to demonstrate that thyroid carcinoma can metastasize to the small bowel. This case report involves a 66-year-old woman who underwent total thyroidectomy surgery in 2019, with histopathology revealing a 3A undifferentiated thyroid cancer. She presented with symptoms of bowel obstruction, including abdominal pain, nausea, and vomiting. Thyroid carcinoma accounts for less than 4% of all malignant neoplasms, making it the most common endocrine malignancy. The predominant type is papillary carcinoma, which generally has a favorable prognosis. In contrast, poorly differentiated thyroid cancers have a poor prognosis, with a 5-year postoperative survival rate of 66%. Common metastatic sites include the lungs, brain, and bones, with rare occurrences in organs such as the kidneys, spleen, adrenal glands, and ovaries. Intestinal metastases are extremely rare, with fewer than 15 cases of gastrointestinal localization documented in the literature. This case highlights the rare possibility of thyroid carcinoma metastasizing to the small bowel, emphasizing the need for clinicians to consider metastatic spread in patients with a history of thyroid cancer who present with gastrointestinal symptoms.
在本文中，我们旨在证明甲状腺癌可转移至小肠。本病例报告涉及一名66岁女性，她于2019年接受了甲状腺全切除术，组织病理学显示为3A期未分化甲状腺癌。她出现了肠梗阻症状，包括腹痛、恶心和呕吐。甲状腺癌占所有恶性肿瘤的比例不到4%，是最常见的内分泌恶性肿瘤。主要类型是乳头状癌，其预后通常较好。相比之下，低分化甲状腺癌预后较差，术后5年生存率为66%。常见的转移部位包括肺、脑和骨，在肾脏、脾脏、肾上腺和卵巢等器官中转移较为罕见。肠道转移极为罕见，文献中记录的胃肠道定位病例少于15例。本病例突出了甲状腺癌转移至小肠的罕见可能性，强调临床医生在有甲状腺癌病史且出现胃肠道症状的患者中考虑转移扩散的必要性。
