Chen Jun-Chen, Zhuang Dong-Zhou, Luo Cheng, Chen Wei-Qiang
Department of Neurosurgery, The First Affiliated Hospital of Shantou University Medical College, Shantou 515041, Guangdong Province, China.
World J Clin Cases. 2021 Apr 26;9(12):2791-2800. doi: 10.12998/wjcc.v9.i12.2791.
Malignant pheochromocytoma with cerebral and skull metastasis is a very rare disease. Combining our case with 16 previously reported cases identified from a PubMed search, an analysis of 17 cases of malignant cerebral pheochromocytoma was conducted. This literature review aimed to provide information on clinical manifestations, radiographic and histopathological features, and treatment strategies of this condition.
A 60-year-old man was admitted with a progressive headache and enlarging scalp mass lasting for 3 mo. Radiographic images revealed a left temporal biconvex-shaped epidural mass and multiple lytic lesions. The patient underwent a left temporal craniotomy for resection of the temporal tumor. Histopathological analysis led to identification of the mass as malignant pheochromocytoma. The patient's symptoms were alleviated at the postoperative 3-mo clinical follow-up. However, metastatic pheochromocytoma lesions were found on the right 6 rib and the 6 to 9 thoracic vertebrae on a 1-year clinical follow-up computed tomography scan.
Magnetic resonance spectroscopy and histopathological examination are necessary to make an accurate differential diagnosis between malignant cerebral pheochromocytoma and meningioma. Surgery is regarded as the first choice of treatment.
伴有脑和颅骨转移的恶性嗜铬细胞瘤是一种非常罕见的疾病。将我们的病例与通过PubMed检索先前报道的16例病例相结合，对17例恶性脑嗜铬细胞瘤病例进行了分析。本综述旨在提供有关该疾病的临床表现、影像学和组织病理学特征以及治疗策略的信息。
一名60岁男性因进行性头痛和头皮肿物增大持续3个月入院。影像学检查显示左侧颞部双凸形硬膜外肿物及多个溶骨性病变。患者接受了左侧颞部开颅手术以切除颞部肿瘤。组织病理学分析确定肿物为恶性嗜铬细胞瘤。术后3个月临床随访时患者症状缓解。然而，在1年临床随访的计算机断层扫描中发现右侧第6肋骨及胸6至胸9椎体有转移性嗜铬细胞瘤病变。
磁共振波谱分析和组织病理学检查对于准确鉴别恶性脑嗜铬细胞瘤和脑膜瘤是必要的。手术被视为首选治疗方法。
