Cassidy Rachel N, Miller Mollie E, Tidey Jennifer W, DiGuiseppi Graham, Denlinger-Apte Rachel L, Colby Suzanne M
Center for Alcohol and Addiction Studies, Brown University.
Tob Regul Sci. 2019 Mar;5(2):105-114. doi: 10.18001/trs.5.2.2.
The FDA is considering the implementation of a national nicotine reduction policy for cigarettes, and such a policy may reduce the reinforcing efficacy of cigarettes and ultimately reduce tobacco dependence. However, it is not yet known how different levels of nicotine may affect the reinforcing efficacy of cigarettes in adolescents. We aimed to determine how reduced nicotine content may affect adolescents' demand for cigarettes using the cigarette purchase task (CPT).
Adolescent daily smokers (ages 15-19, n = 50) completed a CPT for their usual brand cigarette and for each dose of SPECTRUM research cigarettes (15.8, 5.2, 1.3, 0.4 mg nicotine/g tobacco) during four laboratory sessions. We conducted repeated measures ANOVAs to evaluate the effect of nicotine dose on five demand indices derived from the CPT.
Tests revealed significantly higher demand for usual brand than each research cigarette dose (all p's < .01); dose did not significantly affect any measure when usual brand was excluded.
These results demonstrate the potential utility of the CPT for comparing the reinforcing efficacy of cigarettes varying in nicotine content in adolescents, and indicate a significantly reduced reinforcing efficacy of all research cigarettes relative to usual brand.
美国食品药品监督管理局（FDA）正在考虑实施一项针对香烟的全国性尼古丁减量政策，这样一项政策可能会降低香烟的强化效力，并最终减少烟草依赖。然而，不同水平的尼古丁如何影响青少年对香烟的强化效力尚不清楚。我们旨在使用香烟购买任务（CPT）来确定尼古丁含量降低如何影响青少年对香烟的需求。
青少年每日吸烟者（年龄15 - 19岁，n = 50）在四个实验室环节中，针对他们常用品牌香烟以及每剂SPECTRUM研究香烟（尼古丁含量为15.8、5.2、1.3、0.4毫克/克烟草）完成了CPT。我们进行了重复测量方差分析，以评估尼古丁剂量对从CPT得出的五个需求指标的影响。
测试显示，对常用品牌香烟的需求显著高于每种研究香烟剂量（所有p值 < .01）；当排除常用品牌时，剂量对任何指标均无显著影响。
这些结果证明了CPT在比较青少年中尼古丁含量不同的香烟强化效力方面的潜在效用，并表明所有研究香烟相对于常用品牌的强化效力显著降低。
