Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Departments of Psychiatry and Psychological Science, Vermont Center on Behavior and Health, University of Vermont, Burlington, VT, USA.
Drug Alcohol Depend. 2019 Apr 1;197:56-64. doi: 10.1016/j.drugalcdep.2019.01.004. Epub 2019 Feb 13.
Nicotine is the addictive component in cigarettes that maintain cigarette smoking that subsequently leads to morbidity and mortality. Methods for assessing the abuse liability of cigarettes are essential to inform new tobacco product standards. This secondary analysis evaluated the utility of one subjective effects measure, the modified Cigarette Evaluation Questionnaire (mCEQ), and one behavioral economic task, the Cigarette Purchase Task (CPT), for predicting acute relative reinforcing efficacy measured by concurrent choice Self-Administration (SA).
Smokers (N = 169) belonging to one of three vulnerable populations participated in a multi-site, double-blind study evaluating research cigarettes with varying levels of nicotine (0.4, 2.4, 5.2, 15.8 mg/g). Participants sampled cigarettes and completed the mCEQ and CPT. In subsequent sessions, cigarette preference was assessed using a concurrent choice SA procedure. Mixed-model repeated measures analysis of variance tests were used to evaluate the utility of the mCEQ subscales and CPT indices for predicting preference for the higher compared to lower nicotine content cigarettes. In addition, stepwise regressions were used to determine which subscales and indices independently predicted concurrent choice SA.
Greater increases on the Satisfaction and Enjoyment of Respiratory Tract Sensations mCEQ subscales independently predicted higher dose preference in concurrent choice testing. Elasticity was the only CPT index that predicted choice. However, its predictive utility differed by dose among opioid-maintained individuals.
The mCEQ and CPT predict behavioral measures of relative reinforcing efficacy as assessed in concurrent choice SA, with the mCEQ Satisfaction and Enjoyment of Respiratory Tract Sensations subscales being the strongest independent predictors.
尼古丁是香烟中的成瘾成分，维持着吸烟行为，进而导致发病率和死亡率。评估香烟滥用倾向的方法对于告知新的烟草产品标准至关重要。本二次分析评估了一种主观效应测量方法，即改良香烟评价问卷（mCEQ），和一种行为经济学任务，即香烟购买任务（CPT），用于预测通过同时选择自我给药（SA）测量的急性相对强化效力。
属于三个脆弱人群之一的吸烟者（N=169）参加了一项多地点、双盲研究，评估了具有不同尼古丁含量（0.4、2.4、5.2、15.8mg/g）的研究香烟。参与者抽样香烟并完成 mCEQ 和 CPT。在随后的会议中，使用同时选择 SA 程序评估香烟偏好。使用混合模型重复测量方差分析检验评估 mCEQ 分量表和 CPT 指数预测对较高与较低尼古丁含量香烟偏好的效用。此外，使用逐步回归确定哪些分量表和指数独立预测同时选择 SA。
mCEQ 的满意度和呼吸道感觉享受分量表的评分增加越大，独立预测在同时选择测试中对更高剂量的偏好。弹性是唯一预测选择的 CPT 指数。然而，它的预测效用在阿片类药物维持个体中因剂量而异。
mCEQ 和 CPT 预测相对强化效力的行为测量，如在同时选择 SA 中评估，其中 mCEQ 的满意度和呼吸道感觉享受分量表是最强的独立预测因素。
