Sahu Utkarsha, Biswas Debasis, Singh Anirudh Kumar, Khare Prashant
Department of Microbiology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh India.
Virusdisease. 2021 Jun;32(2):211-219. doi: 10.1007/s13337-021-00687-2. Epub 2021 May 4.
SARS CoV-2, a causative agent of human respiratory tract infection, was first identified in late 2019. It is a newly emerging viral disease with unsatisfactory treatments. The virus is highly contagious and has caused pandemic globally. The number of deaths is increasing exponentially, which is an alarming situation for mankind. The detailed mechanism of the pathogenesis and host immune responses to this virus are not fully known. Here we discuss an overview of SARS CoV-2 pathogenicity, its entry and replication mechanism, and host immune response against this deadly pathogen. Understanding these processes will help to lead the development and identification of drug targets and effective therapies.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是人类呼吸道感染的病原体，于2019年末首次被发现。它是一种新出现的病毒性疾病，治疗效果不尽人意。该病毒具有高度传染性，已在全球范围内引发大流行。死亡人数呈指数级增长，这对人类来说是一个令人担忧的情况。该病毒发病机制及宿主免疫反应的详细机制尚不完全清楚。在此，我们将概述SARS-CoV-2的致病性、其进入和复制机制，以及宿主针对这种致命病原体的免疫反应。了解这些过程将有助于推动药物靶点的开发和鉴定以及有效疗法的研发。
