Department of Fisheries, Faculty of Natural Resources, University of Tehran, Karaj, Iran.
Evidence-based Phytotherapy & Complementary Medicine Research Center, Alborz University of Medical Sciences, Karaj, Iran; Department of Pharmaceutics, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran.
Int J Biol Macromol. 2022 Jun 1;209(Pt A):244-257. doi: 10.1016/j.ijbiomac.2022.03.063. Epub 2022 Mar 16.
Covid-19 pandemic severely affected human health worldwide. The rapidly increasing COVID-19 cases and successive mutations of the virus have made it a major challenge for scientists to find the best and efficient drug/vaccine/strategy to counteract the virus pathogenesis. As a result of research in scientific databases, regulating the immune system and its responses with nutrients and nutritional interventions is the most critical solution to prevent and combat this infection. Also, modulating other organs such as the intestine with these compounds can lead to the vaccines' effectiveness. Marine resources, mainly algae, are rich sources of nutrients and bioactive compounds with known immunomodulatory properties and the gut microbiome regulations. According to the purpose of the review, algae-derived bioactive compounds with immunomodulatory activities, sulfated polysaccharides, and polyunsaturated fatty acids have a good effect on the immune system. In addition, they have probiotic/prebiotic properties in the intestine and modulate the gut microbiomes; therefore, they can increase the effectiveness of vaccines produced. Thus, they with respectable safety, immune regulation, and modulation of microbiota have potential therapeutic against infections, especially COVID-19. They can also be employed as promising candidates for the prevention and treatment of viral infections, such as COVID-19.
Covid-19 大流行严重影响了全球人类的健康。COVID-19 病例的迅速增加和病毒的连续突变，使得科学家们很难找到最佳和有效的药物/疫苗/策略来对抗病毒的发病机制。由于在科学数据库中的研究，用营养素和营养干预来调节免疫系统及其反应是预防和对抗这种感染的最关键的解决方案。此外，用这些化合物来调节肠道等其他器官也可以提高疫苗的有效性。海洋资源，主要是藻类，是营养物质和具有已知免疫调节特性和肠道微生物组调节作用的生物活性化合物的丰富来源。根据综述的目的，具有免疫调节活性的藻类来源的生物活性化合物、硫酸多糖和多不饱和脂肪酸对免疫系统有很好的作用。此外，它们在肠道中具有益生菌/益生元特性，并调节肠道微生物组；因此，它们可以提高所产生疫苗的有效性。因此，它们具有令人尊敬的安全性、免疫调节和微生物组调节作用，对感染具有潜在的治疗作用，特别是 COVID-19。它们也可以作为预防和治疗 COVID-19 等病毒感染的有前途的候选药物。
