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1
Elevated plasma free sialic acid levels in individuals with reduced glomerular filtration rates.肾小球滤过率降低个体的血浆游离唾液酸水平升高。
Kidney360. 2020 Sep 24;1(9):957-961. doi: 10.34067/kid.0002122020.
2
Safety, pharmacokinetics and sialic acid production after oral administration of N-acetylmannosamine (ManNAc) to subjects with GNE myopathy.GNE 肌病患者口服 N-乙酰甘露糖胺（ManNAc）后的安全性、药代动力学和唾液酸生成。
Mol Genet Metab. 2017 Sep;122(1-2):126-134. doi: 10.1016/j.ymgme.2017.04.010. Epub 2017 Apr 26.
3
Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine.唾液酸生物合成关键酶的突变导致严重的肾小球蛋白尿，而N-乙酰甘露糖胺可挽救该症状。
J Clin Invest. 2007 Jun;117(6):1585-94. doi: 10.1172/JCI30954.
4
Engineering sialic acid synthetic ability into insect cells: identifying metabolic bottlenecks and devising strategies to overcome them.将唾液酸合成能力引入昆虫细胞：识别代谢瓶颈并设计克服这些瓶颈的策略。
Biochemistry. 2003 Dec 30;42(51):15215-25. doi: 10.1021/bi034994s.
5
Population Pharmacokinetic Model of N-acetylmannosamine (ManNAc) and N-acetylneuraminic acid (Neu5Ac) in Subjects with GNE Myopathy.GNE 肌病患者中 N-乙酰甘露糖胺（ManNAc）和 N-乙酰神经氨酸（Neu5Ac）的群体药代动力学模型。
Drugs R D. 2021 Jun;21(2):189-202. doi: 10.1007/s40268-021-00343-6. Epub 2021 Apr 24.
6
Quantitative hydrophilic interaction chromatography-mass spectrometry analysis of N-acetylneuraminic acid and N-acetylmannosamine in human plasma.人血浆中N-乙酰神经氨酸和N-乙酰甘露糖胺的定量亲水相互作用色谱-质谱分析
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 1;1000:105-11. doi: 10.1016/j.jchromb.2015.07.018. Epub 2015 Jul 17.
7
A novel sugar analog enhances sialic acid production and biotherapeutic sialylation in CHO cells.一种新型糖类似物可增强CHO细胞中唾液酸的产生及生物治疗性唾液酸化作用。
Biotechnol Bioeng. 2017 Aug;114(8):1899-1902. doi: 10.1002/bit.26291. Epub 2017 May 8.
8
Sialic acid supplementation ameliorates puromycin aminonucleoside nephrosis in rats.补充唾液酸可改善大鼠嘌呤霉素氨基核苷肾病。
Lab Invest. 2015 Sep;95(9):1019-28. doi: 10.1038/labinvest.2015.78. Epub 2015 Jun 29.
9
GNE deficiency impairs Myogenesis in C2C12 cells and cannot be rescued by ManNAc supplementation.GNE 缺乏症会损害 C2C12 细胞的成肌分化，而 ManNAc 补充不能挽救这一缺陷。
Glycobiology. 2024 Apr 1;34(3). doi: 10.1093/glycob/cwae004.
10
Evaluation of -Acetylmannosamine Administration to Restore Sialylation in -Deficient Human Embryonal Kidney Cells.评价 N-乙酰甘露糖胺给药以恢复 -缺陷型人胚肾细胞中的唾液酸化。
Front Biosci (Landmark Ed). 2023 Nov 24;28(11):300. doi: 10.31083/j.fbl2811300.

引用本文的文献

1
Sialoglyco-Conjugate Abnormalities, IL-6 Trans-Signaling and Anti-Ganglioside Immune Response-Potential Interferences in Lupus Nephritis Pathogenesis.唾液酸糖缀合物异常、白细胞介素-6转信号传导及抗神经节苷脂免疫反应——狼疮性肾炎发病机制中的潜在干扰因素
Diagnostics (Basel). 2021 Jun 21;11(6):1129. doi: 10.3390/diagnostics11061129.

本文引用的文献

1
Rationale and Design for a Phase 1 Study of -Acetylmannosamine for Primary Glomerular Diseases.α-乙酰甘露糖胺用于原发性肾小球疾病的1期研究的原理与设计
Kidney Int Rep. 2019 Jun 25;4(10):1454-1462. doi: 10.1016/j.ekir.2019.06.012. eCollection 2019 Oct.
2
A phase 3 randomized study evaluating sialic acid extended-release for GNE myopathy.一项评估唾液酸延长释放治疗 GNE 肌病的 3 期随机研究。
Neurology. 2019 Apr 30;92(18):e2109-e2117. doi: 10.1212/WNL.0000000000006932. Epub 2019 Jan 25.
3
A New Patient With Intermediate Severe Salla Disease With Hypomyelination: A Literature Review for Salla Disease.伴有低髓鞘化的中间严重 Salla 病新患者：Salla 病文献复习。
Pediatr Neurol. 2017 Sep;74:87-91.e2. doi: 10.1016/j.pediatrneurol.2017.05.022. Epub 2017 Jun 1.
4
Safety, pharmacokinetics and sialic acid production after oral administration of N-acetylmannosamine (ManNAc) to subjects with GNE myopathy.GNE 肌病患者口服 N-乙酰甘露糖胺（ManNAc）后的安全性、药代动力学和唾液酸生成。
Mol Genet Metab. 2017 Sep;122(1-2):126-134. doi: 10.1016/j.ymgme.2017.04.010. Epub 2017 Apr 26.
5
Quantitative hydrophilic interaction chromatography-mass spectrometry analysis of N-acetylneuraminic acid and N-acetylmannosamine in human plasma.人血浆中N-乙酰神经氨酸和N-乙酰甘露糖胺的定量亲水相互作用色谱-质谱分析
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 1;1000:105-11. doi: 10.1016/j.jchromb.2015.07.018. Epub 2015 Jul 17.
6
Total and free serum sialic acid concentration in liver diseases.肝脏疾病中血清总唾液酸和游离唾液酸浓度
Biomed Res Int. 2014;2014:876096. doi: 10.1155/2014/876096. Epub 2014 May 18.
7
Sialic acid level reflects the disturbances of glycosylation and acute-phase reaction in rheumatic diseases.唾液酸水平反映了风湿性疾病中糖基化和急性期反应的紊乱。
Rheumatol Int. 2014 Mar;34(3):393-9. doi: 10.1007/s00296-013-2921-y. Epub 2013 Dec 18.
8
Estimating glomerular filtration rate from serum creatinine and cystatin C.基于血清肌酐和胱抑素 C 估算肾小球滤过率。
N Engl J Med. 2012 Jul 5;367(1):20-9. doi: 10.1056/NEJMoa1114248.
9
Sialic acids as regulators of molecular and cellular interactions.唾液酸作为分子与细胞相互作用的调节因子。
Curr Opin Struct Biol. 2009 Oct;19(5):507-14. doi: 10.1016/j.sbi.2009.06.003. Epub 2009 Aug 19.
10
Sizing up sialic acid in glomerular disease.评估肾小球疾病中的唾液酸
J Clin Invest. 2007 Jun;117(6):1480-3. doi: 10.1172/JCI32482.

Elevated plasma free sialic acid levels in individuals with reduced glomerular filtration rates.

作者信息

Fuentes Federico, Carrillo Nuria, Wilkins Kenneth J, Blake Jodi, Leoyklang Petcharat, Gahl William A, Kopp Jeffrey B, Huizing Marjan

机构信息

Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Kidney360. 2020 Sep 24;1(9):957-961. doi: 10.34067/kid.0002122020.

DOI:10.34067/kid.0002122020
PMID:33969317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8104432/
Abstract
摘要