Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genova, Genova, Italy.
Int J Gynaecol Obstet. 2022 Mar;156(3):418-424. doi: 10.1002/ijgo.13737. Epub 2021 Jun 8.
Ovarian carcinoma (OC) is one of the most widespread tumors in the world and is characterized by low survival rates.
To determine whether the levonorgestrel-releasing intrauterine system (LNG-IUS) can prevent OC.
The literature until December 2020 were systematically reviewed according to the PRISMA Statement for Reporting Systematic Reviews (PROSPERO: CRD42019137957).
Studies assessing the impact of LNG-IUS on the risk of OC were included.
Data were extracted independently by two authors to ensure accuracy and consistency.
A total of 34 323 records were obtained, of which three satisfied the inclusion criteria. In total, 1687 events of OC in a population of 20 461 311 person-years were considered. Data pooling revealed that the use of LNG-IUS did not confer a lower risk of OC relative to the never-use of LNG-IUS, with an estimated odds ratio of 0.66 (95% confidence interval 0.41-1.08; I = 84%; P = 0.002).
The meta-analysis did not demonstrate a preventive role of LNG-IUS on OC. However, it was carried out on a few papers, and a definitive conclusion on the topic still cannot be drawn. Further studies are indicated in the future to define the impact of LNG-IUS on OC. The meta-analysis carried out on three papers did not demonstrate a preventive role of the levonorgestrel-releasing intrauterine device on ovarian cancer.
卵巢癌（OC）是世界上最广泛的肿瘤之一，其特征是生存率低。
确定左炔诺孕酮释放宫内节育系统（LNG-IUS）是否可以预防 OC。
根据 PRISMA 声明（PROSPERO：CRD42019137957）系统地回顾了截至 2020 年 12 月的文献。
包括评估 LNG-IUS 对 OC 风险影响的研究。
两名作者独立提取数据，以确保准确性和一致性。
共获得 34323 条记录，其中 3 条符合纳入标准。共考虑了 20461311 人年的人群中 1687 例 OC 事件。数据合并显示，与从未使用 LNG-IUS 相比，使用 LNG-IUS 并不能降低 OC 的风险，估计比值比为 0.66（95%置信区间 0.41-1.08；I = 84%；P = 0.002）。
荟萃分析并未显示 LNG-IUS 对 OC 有预防作用。然而，它是基于少数几篇论文进行的，因此仍然无法得出关于该主题的明确结论。未来需要进一步的研究来确定 LNG-IUS 对 OC 的影响。对三篇论文的荟萃分析并未显示左炔诺孕酮释放宫内节育器对卵巢癌有预防作用。
