布线和管道：少突胶质前体细胞和血管生成在寡血管龛中。
Wiring and plumbing: Oligodendrocyte precursors and angiogenesis in the oligovascular niche.
机构信息
Neuroprotection Research Laboratories, Departments of Radiology and Neurology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
出版信息
J Cereb Blood Flow Metab. 2021 Aug;41(8):2132-2133. doi: 10.1177/0271678X211014979. Epub 2021 May 9.
Abstract
For efficient stroke recovery, the entire neurovascular unit must be repaired. A recent study underscores this concept by highlighting the importance of cellular crosstalk for white mater remodeling. In developing brains and in brains injured by hypoxia, interactions between oligodendrocyte precursors and endothelium play an essential role for physiological and compensatory angiogenesis. Further studies are warranted to build on these emerging findings in the oligovascular niche in order to identify novel therapeutic targets for stroke and other CNS diseases.
摘要
为了实现有效的中风康复，必须修复整个神经血管单元。最近的一项研究强调了细胞串扰对白质重塑的重要性，突出了这一概念。在发育中的大脑和缺氧损伤的大脑中，少突胶质前体细胞与内皮细胞之间的相互作用对于生理性和代偿性血管生成起着至关重要的作用。进一步的研究是必要的，以建立在这些新兴的发现中的少血管龛，以确定中风和其他中枢神经系统疾病的新的治疗靶点。
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本文引用的文献
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Wnt-Dependent Oligodendroglial-Endothelial Interactions Regulate White Matter Vascularization and Attenuate Injury.Wnt 依赖性少突胶质细胞-血管内皮相互作用调节白质血管生成并减轻损伤。
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Can oligodendrocyte precursor cells be a therapeutic target for mitigating cognitive decline in cerebrovascular disease?少突胶质前体细胞能否成为减轻脑血管病认知衰退的治疗靶点？
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