Department of Orthopaedic Surgery, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, OH, USA.
Department of Orthopaedic Surgery, Stanford University Medical Center, Palo Alto, CA, USA.
Cartilage. 2021 Dec;13(1_suppl):1250S-1257S. doi: 10.1177/19476035211011515. Epub 2021 May 8.
The objective of this study is to compare the (1) reoperation rates, (2) 30-day complication rates, and (3) cost differences between patients undergoing isolated autologous chondrocyte implantation (ACI) or osteochondral allograft transplantation (OCA) procedures alone versus patients with concomitant osteotomy.
Retrospective cohort study, level III.
Patients who underwent knee ACI (Current Procedural Terminology [CPT] 27412) or OCA (CPT 27415) with minimum 2-year follow-up were queried from a national insurance database. Resulting cohorts of patients that underwent ACI and OCA were then divided into patients who underwent isolated cartilage restoration procedure and patients who underwent concomitant osteotomy (CPT 27457, 27450, 27418). Reoperation was defined by ipsilateral knee procedure after the index surgery. The 30-day postoperative complication rates were assessed using ICD-9-CM codes. The cost per patient was calculated.
A total of 1,113 patients (402 ACI, 67 ACI + osteotomy, 552 OCA, 92 OCA + osteotomy) were included (mean follow-up of 39.0 months). Reoperation rate was significantly higher after isolated ACI or OCA compared to ACI or OCA plus concomitant osteotomy (ACI 68.7% vs. ACI + osteotomy 23.9%; OCA 34.8% vs. OCA + osteotomy 16.3%). Overall complication rates were similar between isolated ACI (3.0%) and ACI + osteotomy (4.5%) groups and OCA (2.5%) and OCA + osteotomy (3.3%) groups. Payments were significantly higher in the osteotomy groups at day of surgery and 9 months compared to isolated ACI or OCA, but costs were similar by 2 years postoperatively.
Concomitant osteotomy at the time of index ACI or OCA procedure significantly reduces the risk of reoperation with a similar rate of complications and similar overall costs compared with isolated ACI or OCA.
本研究旨在比较(1)翻修率、(2)30 天并发症发生率和(3)单独行自体软骨细胞移植(ACI)或骨软骨异体移植(OCA)与同期行截骨术患者的成本差异。
回顾性队列研究,III 级。
从全国性保险数据库中查询了接受膝关节 ACI(当前程序术语 [CPT] 27412)或 OCA(CPT 27415)治疗且随访至少 2 年的患者。然后将接受 ACI 和 OCA 的患者分为单纯软骨修复术患者和同期行截骨术患者(CPT 27457、27450、27418)。同侧膝关节手术后再次手术定义为翻修。使用 ICD-9-CM 代码评估 30 天术后并发症发生率。计算每位患者的成本。
共纳入 1113 例患者(402 例 ACI、67 例 ACI+截骨术、552 例 OCA、92 例 OCA+截骨术)(平均随访 39.0 个月)。与同期行截骨术患者相比,单纯 ACI 或 OCA 患者的翻修率显著更高(ACI 68.7% vs. ACI+截骨术 23.9%;OCA 34.8% vs. OCA+截骨术 16.3%)。单纯 ACI(3.0%)和同期行截骨术(4.5%)组与单纯 OCA(2.5%)和同期行截骨术(3.3%)组的总体并发症发生率相似。与单纯 ACI 或 OCA 相比,同期行截骨术患者在手术当天和 9 个月时的支付费用显著更高,但在术后 2 年时费用相似。
与单纯 ACI 或 OCA 相比,同期行 ACI 或 OCA 手术时同期行截骨术可显著降低翻修风险,且并发症发生率和总体成本相似。