HDAC Inhibition in the Heart: Erasing Hidden Fibrosis.
作者信息
Gillette Thomas G
机构信息
Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.
出版信息
Circulation. 2021 May 11;143(19):1891-1893. doi: 10.1161/CIRCULATIONAHA.121.054262. Epub 2021 May 10.
Abstract
摘要
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本文引用的文献
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HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling.组蛋白去乙酰化酶抑制逆转预先存在的舒张功能障碍并阻止隐匿性细胞外基质重塑。
Circulation. 2021 May 11;143(19):1874-1890. doi: 10.1161/CIRCULATIONAHA.120.046462. Epub 2021 Mar 8.
2
Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.三十年 HDAC 抑制剂：2020 年的新视角和新认识。
J Med Chem. 2020 Nov 12;63(21):12460-12484. doi: 10.1021/acs.jmedchem.0c00830. Epub 2020 Jul 16.
3
HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction.组蛋白去乙酰化酶抑制改善舒张功能障碍猫模型的心肺功能。
Sci Transl Med. 2020 Jan 8;12(525). doi: 10.1126/scitranslmed.aay7205.
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The Extracellular Matrix in Ischemic and Nonischemic Heart Failure.缺血性和非缺血性心力衰竭中的细胞外基质。
Circ Res. 2019 Jun 21;125(1):117-146. doi: 10.1161/CIRCRESAHA.119.311148. Epub 2019 Jun 20.
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Nitrosative stress drives heart failure with preserved ejection fraction.硝化应激导致射血分数保留型心力衰竭。
Nature. 2019 Apr;568(7752):351-356. doi: 10.1038/s41586-019-1100-z. Epub 2019 Apr 10.
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Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism.组蛋白去乙酰化酶活性通过非基因组机制调控舒张功能障碍。
Sci Transl Med. 2018 Feb 7;10(427). doi: 10.1126/scitranslmed.aao0144.
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Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression.I类组蛋白去乙酰化酶的抑制通过TSC2依赖的mTOR抑制减轻心脏肥大。
Sci Signal. 2016 Apr 5;9(422):ra34. doi: 10.1126/scisignal.aad5736.
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Biochim Biophys Acta. 2014 Aug;1839(8):627-43. doi: 10.1016/j.bbagrm.2014.03.001. Epub 2014 Mar 12.
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Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy.组蛋白去乙酰化酶抑制通过诱导心肌细胞自噬减轻缺血/再灌注损伤。
Circulation. 2014 Mar 11;129(10):1139-51. doi: 10.1161/CIRCULATIONAHA.113.002416. Epub 2014 Jan 6.
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