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HDAC Inhibition in the Heart: Erasing Hidden Fibrosis.

作者信息

Gillette Thomas G

机构信息

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas.

出版信息

Circulation. 2021 May 11;143(19):1891-1893. doi: 10.1161/CIRCULATIONAHA.121.054262. Epub 2021 May 10.

DOI:10.1161/CIRCULATIONAHA.121.054262
PMID:33970677
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8162936/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d7a/8162936/f2e994372a23/nihms-1693268-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d7a/8162936/f2e994372a23/nihms-1693268-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d7a/8162936/f2e994372a23/nihms-1693268-f0001.jpg

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本文引用的文献

1
HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling.组蛋白去乙酰化酶抑制逆转预先存在的舒张功能障碍并阻止隐匿性细胞外基质重塑。
Circulation. 2021 May 11;143(19):1874-1890. doi: 10.1161/CIRCULATIONAHA.120.046462. Epub 2021 Mar 8.
2
Thirty Years of HDAC Inhibitors: 2020 Insight and Hindsight.三十年 HDAC 抑制剂:2020 年的新视角和新认识。
J Med Chem. 2020 Nov 12;63(21):12460-12484. doi: 10.1021/acs.jmedchem.0c00830. Epub 2020 Jul 16.
3
HDAC inhibition improves cardiopulmonary function in a feline model of diastolic dysfunction.
Pharmaceuticals (Basel). 2024 Oct 10;17(10):1353. doi: 10.3390/ph17101353.
4
Unlocking Macrophage Secrets: Histone Deacetylases in Chronic Transplant Rejection.揭开巨噬细胞的秘密:慢性移植排斥反应中的组蛋白去乙酰化酶。
Results Probl Cell Differ. 2024;74:297-313. doi: 10.1007/978-3-031-65944-7_12.
5
Fibroblast Diversity and Epigenetic Regulation in Cardiac Fibrosis.成纤维细胞多样性及其在心脏纤维化中的表观遗传调控
Int J Mol Sci. 2024 May 30;25(11):6004. doi: 10.3390/ijms25116004.
6
The recent advance and prospect of natural source compounds for the treatment of heart failure.用于治疗心力衰竭的天然来源化合物的最新进展与展望
Heliyon. 2024 Feb 25;10(5):e27110. doi: 10.1016/j.heliyon.2024.e27110. eCollection 2024 Mar 15.
7
Traditional Therapeutics and Potential Epidrugs for CVD: Why Not Both?心血管疾病的传统疗法与潜在的表观遗传药物:为何不兼而用之?
Life (Basel). 2023 Dec 22;14(1):23. doi: 10.3390/life14010023.
8
Prediction of histone deacetylase inhibition by triazole compounds based on artificial intelligence.基于人工智能的三唑化合物对组蛋白去乙酰化酶抑制作用的预测
Front Pharmacol. 2023 Nov 15;14:1260349. doi: 10.3389/fphar.2023.1260349. eCollection 2023.
9
The role of P21-activated kinase (Pak1) in sinus node function.P21 激活激酶(Pak1)在窦房结功能中的作用。
J Mol Cell Cardiol. 2023 Jun;179:90-101. doi: 10.1016/j.yjmcc.2023.04.004. Epub 2023 Apr 20.
10
Inflammatory Mechanisms in Heart Failure with Preserved Ejection Fraction.射血分数保留的心力衰竭中的炎症机制。
Physiology (Bethesda). 2023 Sep 1;38(5):0. doi: 10.1152/physiol.00004.2023. Epub 2023 Apr 4.
组蛋白去乙酰化酶抑制改善舒张功能障碍猫模型的心肺功能。
Sci Transl Med. 2020 Jan 8;12(525). doi: 10.1126/scitranslmed.aay7205.
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The Extracellular Matrix in Ischemic and Nonischemic Heart Failure.缺血性和非缺血性心力衰竭中的细胞外基质。
Circ Res. 2019 Jun 21;125(1):117-146. doi: 10.1161/CIRCRESAHA.119.311148. Epub 2019 Jun 20.
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Nitrosative stress drives heart failure with preserved ejection fraction.硝化应激导致射血分数保留型心力衰竭。
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Histone deacetylase activity governs diastolic dysfunction through a nongenomic mechanism.组蛋白去乙酰化酶活性通过非基因组机制调控舒张功能障碍。
Sci Transl Med. 2018 Feb 7;10(427). doi: 10.1126/scitranslmed.aao0144.
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Inhibition of class I histone deacetylases blunts cardiac hypertrophy through TSC2-dependent mTOR repression.I类组蛋白去乙酰化酶的抑制通过TSC2依赖的mTOR抑制减轻心脏肥大。
Sci Signal. 2016 Apr 5;9(422):ra34. doi: 10.1126/scisignal.aad5736.
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Readers, writers, and erasers: chromatin as the whiteboard of heart disease.读取器、写入器和擦除器:作为心脏病白板的染色质
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Interpreting the language of histone and DNA modifications.解读组蛋白和DNA修饰的语言。
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Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy.组蛋白去乙酰化酶抑制通过诱导心肌细胞自噬减轻缺血/再灌注损伤。
Circulation. 2014 Mar 11;129(10):1139-51. doi: 10.1161/CIRCULATIONAHA.113.002416. Epub 2014 Jan 6.