Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, The Netherlands.
Int J Dent Hyg. 2022 Feb;20(1):40-52. doi: 10.1111/idh.12510. Epub 2021 Jul 19.
The present study aimed to establish the efficacy of sodium hypochlorite mouthwash (NaOCl-MW) compared with a control mouthwash on plaque and clinical parameters of periodontal disease.
MEDLINE-PubMed, Embase and Cochrane-CENTRAL databases were searched for clinical trials on patients with gingivitis or periodontitis that assessed the effect of NaOCl-MW in comparison with a negative or positive control on plaque index (PI), gingival index (GI), and bleeding index (BI) scores and probing pocket depth (PPD). Data were extracted from the eligible studies.
Seven eligible papers were retrieved, which together represented six clinical trials. The studies showed considerable heterogeneity regarding methodological and clinical aspects that did not permit a meta-analysis. Two of the three studies in which NaOCl-MW was compared with a negative control showed that NaOCl-MW significantly reduced PI, GI and BI, and no effect was found on PPD. In three studies, NaOCl-MW was assessed using chlorhexidine mouthwash (CHX-MW) as a positive control; no difference was found for GI and BI. One of the three comparisons showed a statistically significant PI score favouring NaOCl-MW. One study measured PPD and found it to be significant in favour of NaOCl-MW.
Studies with a negative control group provided very weak quality evidence for a very small beneficial effect of NaOCl-MW on PI, GI and BI scores. Studies with a positive control group provided very weak quality evidence that NaOCl-MW had a similar effect as CHX-MW on PI, GI and BI scores. The outcome for PPD was inconclusive.
本研究旨在评估次氯酸钠漱口水（NaOCl-MW）与对照漱口水相比在控制菌斑和牙周病临床参数方面的疗效。
在 MEDLINE-PubMed、Embase 和 Cochrane-CENTRAL 数据库中检索了关于牙龈炎或牙周炎患者的临床试验，评估了 NaOCl-MW 与阴性或阳性对照在菌斑指数（PI）、牙龈指数（GI）、出血指数（BI）评分和探诊袋深度（PPD）方面的效果。从合格研究中提取数据。
共检索到 7 篇合格文献，其中有 6 项临床试验。这些研究在方法学和临床方面存在很大的异质性，不允许进行荟萃分析。在 3 项将 NaOCl-MW 与阴性对照进行比较的研究中，有 2 项研究表明，NaOCl-MW 显著降低了 PI、GI 和 BI，而对 PPD 没有影响。在 3 项研究中，NaOCl-MW 用洗必泰漱口水（CHX-MW）作为阳性对照进行评估；GI 和 BI 无差异。其中 3 项比较中的一项显示，NaOCl-MW 的 PI 评分具有统计学意义。有一项研究测量了 PPD，发现 NaOCl-MW 有显著的效果。
有阴性对照组的研究提供了非常微弱的质量证据，表明 NaOCl-MW 对 PI、GI 和 BI 评分有非常小的有益作用。有阳性对照组的研究提供了非常微弱的质量证据，表明 NaOCl-MW 在 PI、GI 和 BI 评分方面与 CHX-MW 具有相似的效果。PPD 的结果尚无定论。
