REQUIMTE-LAQV, Laboratório de Bromatologia e Farmacognosia, Faculdade de Farmácia da Universidade de Coimbra, Polo III, Azinhaga de Sta Comba, 3000-548, Coimbra, Portugal.
REQUIMTE-LAQV, Laboratório de Bromatologia e Farmacognosia, Faculdade de Farmácia da Universidade de Coimbra, Polo III, Azinhaga de Sta Comba, 3000-548, Coimbra, Portugal; Centro de Investigação Vasco da Gama (CIVG)/ Departamento de Ciências Veterinárias, Escola Universitária Vasco da Gama (EUVG), Av. José R. Sousa Fernandes 197, Campus Universitário de Lordemão, 3020-210, Coimbra, Portugal.
Environ Res. 2021 Jul;198:111294. doi: 10.1016/j.envres.2021.111294. Epub 2021 May 7.
The use of glyphosate has been increasing over the years, making it one of the most consumed herbicides in the world. Although children are considered a vulnerable population, only four previous published studies determined glyphosate in the urine of non-occupationally exposed children. The paucity of epidemiological data and biomonitoring surveys are considered major gaps, that hinder the implementation of science driven policies in the protection of public health. The aim of the present study was to determine glyphosate in the urine of 41 Portuguese children (2-13 years old) and identify potential determinants of exposure. Glyphosate was detected in 95.1% of the samples (1.77 ± 0.86 μg/L), up to a maximum value of 4.35 μg/L. Glyphosate concentrations were higher in the urine of children aged 7-9 years, living near agricultural areas (<1 km), with a higher percentage of consumption of home-produced foods, and whose parents applied herbicides in the backyard. Risk assessment revealed an exposure representing 1-5.58% of the established Acceptable Daily Intake (ADI) of glyphosate (0.5 mg/kg bw/day). The results should be further analyzed considering the age of the participants, for which no adjusted ADI exists. This was the first published report of glyphosate exposure in the urine of Portuguese children.
草甘膦的使用量逐年增加，使其成为世界上使用量最大的除草剂之一。尽管儿童被认为是弱势群体，但之前仅有四项已发表的研究报告了非职业接触儿童尿液中的草甘膦含量。缺乏流行病学数据和生物监测调查被认为是主要的差距，这阻碍了以科学为导向的政策在保护公众健康方面的实施。本研究旨在检测 41 名葡萄牙儿童（2-13 岁）尿液中的草甘膦含量，并确定暴露的潜在决定因素。95.1%的样本中检测到草甘膦（1.77±0.86μg/L），最高值达 4.35μg/L。7-9 岁、居住在农业区（<1km）附近、食用自家生产食品比例较高且父母在后院使用除草剂的儿童尿液中草甘膦浓度较高。风险评估显示，暴露量代表已建立的草甘膦每日允许摄入量（ADI）（0.5mg/kg bw/day）的 1-5.58%。应进一步分析参与者的年龄因素，因为目前尚无针对该年龄组的 ADI 值。这是首次报道葡萄牙儿童尿液中的草甘膦暴露情况。
