Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, PR China.
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, PR China; Institute for Translational Brain Research, Shanghai Medical College, Fudan University, Shanghai, PR China; Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai Clinical Medical Center of Neurosurgery, MOE Frontiers Center for Brain Science, Shanghai Medical College, Fudan University, Shanghai, PR China.
Semin Cancer Biol. 2022 Nov;86(Pt 2):990-997. doi: 10.1016/j.semcancer.2021.05.005. Epub 2021 May 7.
The gut-brain axis has paved our way in understanding varieties of disease. The gut microbiota especially the bacterial population plays critical roles in immune system development and function. Glioma comprises 80 percent of malignant brain cancer and glioblastoma (GBM) is the most malignant kind. GBM has a reputation for its suppressive immune environment and poor patient prognosis. Moreover, altered metabolites from gut microbiota affect both systemic immune and central nervous system (CNS) immunity. Here we will focus on the crosstalk between gut microbiota and GBM, and further explore how this communication contributes to glioma initiation and development. Finally, we highlight the latest insights on the metabolic regulation of immunity through gut microbiota, which provides a promising therapeutic strategy for GBM.
肠脑轴为我们理解多种疾病开辟了道路。肠道微生物群，尤其是细菌群体，在免疫系统的发育和功能中发挥着关键作用。神经胶质瘤占恶性脑癌的 80%，其中胶质母细胞瘤（GBM）是最恶性的一种。GBM 因其抑制性免疫环境和较差的患者预后而臭名昭著。此外，来自肠道微生物群的代谢物改变会影响全身免疫和中枢神经系统（CNS）免疫。在这里，我们将重点关注肠道微生物群与 GBM 之间的相互作用，并进一步探讨这种交流如何促进神经胶质瘤的发生和发展。最后，我们强调了通过肠道微生物群对免疫代谢的最新见解，这为 GBM 提供了一种有前途的治疗策略。
