Qi Fan, Meng Kaiqiang, Zhao Xiaoping, Lv Jing, Huang Lan, Fan Xiaoxuan, Feng Zhaoqun
College of Integrated Traditional and Western Medicine, Shaanxi University of Chinese Medicine, Shaanxi, China.
College of Traditional Chinese Medicine, Shaanxi University of Chinese Medicine, Shaanxi, China.
Front Neurol. 2025 Mar 21;16:1549465. doi: 10.3389/fneur.2025.1549465. eCollection 2025.
Glioma, being one of the malignant tumors with the highest mortality rate globally, has an unclear pathogenesis, and the existing treatment effects still have certain limitations. The tumor microenvironment (TME) plays an important role in the occurrence, development, and recurrence of glioma. As one of the important regulatory factors of TME, the gut microbiota can regulate the progression of glioma not only by interacting with the brain through the brain-gut axis but also by influencing the tumor immune microenvironment (TIME) and inflammatory microenvironment. Recent studies have identified the gut microbiota and TME as potential therapeutic targets for glioma. This paper aims to summarize the role of the gut microbiota in TME, the association between them and glioma, and the potential of developing new intervention measures by targeting the gut microbiota. Understanding the involvement process of the gut microbiota in glioma may pave the way for the development of effective treatment methods that can regulate TME and prevent disease progression.
胶质瘤是全球死亡率最高的恶性肿瘤之一，其发病机制尚不清楚，现有治疗效果仍存在一定局限性。肿瘤微环境（TME）在胶质瘤的发生、发展和复发中起重要作用。作为TME的重要调节因子之一，肠道微生物群不仅可以通过脑-肠轴与大脑相互作用，还可以通过影响肿瘤免疫微环境（TIME）和炎症微环境来调节胶质瘤的进展。最近的研究已将肠道微生物群和TME确定为胶质瘤的潜在治疗靶点。本文旨在总结肠道微生物群在TME中的作用、它们与胶质瘤之间的关联以及通过靶向肠道微生物群开发新干预措施的潜力。了解肠道微生物群在胶质瘤中的参与过程可能为开发能够调节TME并预防疾病进展的有效治疗方法铺平道路。
