Department of Medical Laser, Medical Laser Research Center, YARA Institute, ACECR, Tehran, Iran.
Department of Photodynamic, Medical Laser Research Center, YARA Institute, ACECR, Tehran, Iran.
Photodiagnosis Photodyn Ther. 2021 Jun;34:102326. doi: 10.1016/j.pdpdt.2021.102326. Epub 2021 May 7.
Cancer remains common and often is difficult to eradicate. In particular resistant forms like triple negative breast cancer and melanoma generally allow for very short survival. Curcumin and quercetin as two important polyphenols from plants which have different biological roles, potentially including anti-cancer effect. But their clinical application is limited due to poor solubility in aqueous medium. Photodynamic therapy (PDT) is a cancer treatment using select chemical compounds as photosensitizers, which when activated by light create toxic singlet oxygen. Studies done on plant based photosensitizers such as curcumin and quercetin have shown the ability to ablate tumors. Here we discuss using them as improved PS by making their complex with cerium ions as a delivery system for MDA-MB-231 and A375 cancer cell lines treatment. For this purpose, the MDA-MB-231 human breast cancer cell line exposed to red light irradiation (as pretreatment) then treated with curcumin and quercetin alone and also their complex with cerium. In another study the cells treated with curcumin-cerium and quercetin-cerium complex and then irradiated with blue light (photodynamic treatment). Cell survival and apoptosis were determined using MTT and fluorescence microscopy. The result showed that curcumin and quercetin in complex with cerium ions have better toxic effect against both breast and melanoma cancer cells as compared to each compound alone. The finding revealed that curcumin and quercetin in cerium complex could be considered as a new approach in the photodynamic treatment of breast and melanoma cancer cells.
癌症仍然很常见，而且往往难以根除。特别是像三阴性乳腺癌和黑色素瘤这样的耐药形式，通常只能存活很短的时间。姜黄素和槲皮素是两种来自植物的重要多酚类物质，具有不同的生物学作用，可能包括抗癌作用。但由于在水介质中的溶解度差，它们的临床应用受到限制。光动力疗法（PDT）是一种使用特定化学化合物作为光敏剂的癌症治疗方法，这些化合物在光的激活下会产生有毒的单线态氧。对姜黄素和槲皮素等植物来源的光敏剂的研究表明，它们有能力消融肿瘤。在这里，我们讨论了通过将它们与铈离子形成复合物来提高它们的光敏剂性能，作为 MDA-MB-231 和 A375 癌细胞系治疗的递送系统。为此，将 MDA-MB-231 人乳腺癌细胞系暴露于红光照射下（作为预处理），然后单独用姜黄素和槲皮素以及它们与铈的复合物进行处理。在另一项研究中，用姜黄素-铈和槲皮素-铈复合物处理细胞，然后用蓝光照射（光动力治疗）。使用 MTT 和荧光显微镜测定细胞存活率和细胞凋亡。结果表明，与单独使用每种化合物相比，姜黄素和槲皮素与铈离子形成复合物对乳腺癌和黑色素瘤癌细胞具有更好的毒性作用。研究结果表明，姜黄素和槲皮素与铈的复合物可以被认为是一种治疗乳腺癌和黑色素瘤细胞的新方法。
