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基于证据的 COVID-19 门诊治疗策略的应用:预防重症的多学科医疗实践原则。

Application of an evidence-based, out-patient treatment strategy for COVID-19: Multidisciplinary medical practice principles to prevent severe disease.

机构信息

Laboratory of Neuroimmunology, Professor Lawrence Steinman, Stanford University School of Medicine, United States of America.

Department of Neurology, LSU Health Sciences Center New Orleans, Louisiana, United States of America.

出版信息

J Neurol Sci. 2021 Jul 15;426:117463. doi: 10.1016/j.jns.2021.117463. Epub 2021 Apr 20.

DOI:10.1016/j.jns.2021.117463
PMID:33971376
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8055502/
Abstract

The COVID-19 pandemic has devastated individuals, families, and institutions throughout the world. Despite the breakneck speed of vaccine development, the human population remains at risk of further devastation. The decision to not become vaccinated, the protracted rollout of available vaccine, vaccine failure, mutational forms of the SARS virus, which may exhibit mounting resistance to our molecular strike at only one form of the viral family, and the rapid ability of the virus(es) to hitch a ride on our global transportation systems, means that we are will likely continue to confront an invisible, yet devastating foe. The enemy targets one of our human physiology's most important and vulnerable life-preserving body tissues, our broncho-alveolar gas exchange apparatus. Notwithstanding the fear and the fury of this microbe's potential to raise existential questions across the entire spectrum of human endeavor, the application of an early treatment intervention initiative may represent a crucial tool in our defensive strategy. This strategy is driven by evidence-based medical practice principles, those not likely to become antiquated, given the molecular diversity and mutational evolution of this very clever "world traveler".

摘要

新冠疫情已经在全球范围内摧毁了个人、家庭和机构。尽管疫苗研发速度很快,但人类仍面临进一步破坏的风险。不接种疫苗的决定、可用疫苗的缓慢推出、疫苗失效、SARS 病毒的突变形式,这些可能对我们针对病毒家族单一形式的分子攻击表现出越来越强的抵抗力,以及病毒在我们的全球交通系统上迅速传播的能力,这意味着我们可能会继续面临一个无形但具有毁灭性的敌人。这个敌人针对的是我们人体生理学中最重要和最脆弱的维持生命的组织之一,我们的支气管肺泡气体交换装置。尽管这种微生物有可能在人类活动的各个领域引发存在主义问题,引起人们的恐惧和愤怒,但早期治疗干预措施的应用可能代表着我们防御策略中的一个关键工具。该策略基于循证医学实践原则,鉴于这种非常聪明的“世界旅行者”的分子多样性和突变进化,这些原则不太可能过时。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a83/8055502/c4df7e5b8a94/t2a_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a83/8055502/41068f074347/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a83/8055502/2a8e24e976e5/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a83/8055502/b7620fb6ad47/t1a_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a83/8055502/9f751094263b/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a83/8055502/c4df7e5b8a94/t2a_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a83/8055502/41068f074347/fx1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a83/8055502/2a8e24e976e5/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a83/8055502/b7620fb6ad47/t1a_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a83/8055502/9f751094263b/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7a83/8055502/c4df7e5b8a94/t2a_lrg.jpg

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本文引用的文献

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Dietary Supplements and Nutraceuticals under Investigation for COVID-19 Prevention and Treatment.正在接受新冠病毒预防和治疗研究的膳食补充剂与营养保健品
mSystems. 2021 May 4;6(3):e00122-21. doi: 10.1128/mSystems.00122-21.
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'Long COVID' syndrome.长新冠综合征。
BMJ Case Rep. 2021 Apr 19;14(4):e241485. doi: 10.1136/bcr-2020-241485.
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Perspective: Nutritional Strategies Targeting the Gut Microbiome to Mitigate COVID-19 Outcomes.观点:针对肠道微生物组的营养策略以减轻 COVID-19 结局
Adv Nutr. 2021 Jul 30;12(4):1074-1086. doi: 10.1093/advances/nmab031.
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Correlation of autopsy pathological findings and imaging features from 9 fatal cases of COVID-19 pneumonia.COVID-19 肺炎 9 例死亡病例尸检病理发现与影像学特征的相关性。
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