Pediatric Nephrology Unit, Pediatrics Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Saudi Society of Nephrology and Transplantation (SSN&T), Riyadh, Saudi Arabia.
Syst Rev. 2021 May 10;10(1):144. doi: 10.1186/s13643-021-01666-w.
Nephrotic syndrome is the most common kidney disease in children worldwide. Our aim was to critically appraise the quality of recent Clinical Practice Guidelines (CPGs) for idiopathic steroid-sensitive nephrotic syndrome (SSNS) in children in addition to summarize and compare their recommendations.
Systematic review of CPGs. We identified clinical questions and eligibility criteria and searched and screened for CPGs using bibliographic and CPG databases. Each included CPG was assessed by four independent appraisers using the Appraisal of Guidelines for REsearch & Evaluation II (AGREE-II) instrument. We summarized the recommendations in a comparison practical table.
Our search retrieved 282 citations, of which three CPGs were eligible and appraised: Kidney Disease: Improving Global Outcomes (KDIGO) 2012, Japan Society for Pediatric Nephrology (JSPN) 2014, and American Academy of Pediatrics (AAP) 2009. Among these, the overall assessment of two evidence-based CPGs scored > 70% (KDIGO and JSPN), which was consistent with their higher scores in the six domains of the AGREE II Instrument. In domain 3 (rigor of development), KDIGO, JSPN, and AAP scored 84%, 74%, and 41%, respectively. In domain 5 (applicability), they scored 22%, 16%, and 19%, respectively, and in domain 6 (editorial independence), they scored 94%, 65%, and 88%, respectively.
The methodological quality of the KDIGO CPG was superior, followed by JSPN and AAP CPGs with the relevant recommendations for use in practice.
The protocol was registered in the Center for Open Science (OSF) DOI: 10.17605/OSF.IO/6QTMD and in the International prospective register of systematic reviews PROSPERO 2020 CRD42020197511 .
肾病综合征是全球儿童中最常见的肾脏疾病。我们的目的是批判性地评价最近的儿童特发性激素敏感性肾病综合征（SSNS）临床实践指南（CPG）的质量，此外还总结并比较了它们的建议。
CPG 的系统评价。我们确定了临床问题和纳入标准，并使用书目和 CPG 数据库搜索和筛选 CPG。每个纳入的 CPG 均由四位独立评估员使用评估指南研究与评估 II（AGREE-II）工具进行评估。我们在比较实用表中总结了建议。
我们的搜索检索到 282 条引文，其中有 3 条 CPG 符合条件并进行了评估：肾脏病：改善全球结果（KDIGO）2012 年、日本小儿肾脏病学会（JSPN）2014 年和美国儿科学会（AAP）2009 年。在这些指南中，两项基于证据的 CPG 的总体评估得分均超过 70%（KDIGO 和 JSPN），这与它们在 AGREE II 工具的六个领域中的较高得分一致。在领域 3（开发的严谨性）中，KDIGO、JSPN 和 AAP 的得分为 84%、74%和 41%。在领域 5（适用性）中，它们的得分为 22%、16%和 19%，在领域 6（编辑独立性）中，它们的得分为 94%、65%和 88%。
KDIGO CPG 的方法学质量较高，其次是 JSPN 和 AAP CPG，其相关建议可用于实践。
该方案在开放科学中心（OSF）DOI：10.17605/OSF.IO/6QTMD 和国际前瞻性系统评价注册 PROSPERO 2020 CRD42020197511 进行了注册。
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