Amer Yasser S, Shaiba Lana A, Hadid Adnan, Anabrees Jasim, Almehery Abdulrahman, AAssiri Manal, Alnemri Abdulrahman, Darwish Amira R Al, Baqawi Badi, Aboshaiqah Ahmad, Hneiny Layal, Almaghrabi Rana H, El-Malky Ahmed M, Al-Dajani Nawaf M
Pediatrics Department, King Khalid University Hospital, Riyadh, Saudi Arabia.
Clinical Practice Guidelines and Quality Research Unit, Quality Management Department, King Saud University Medical City, Riyadh, Saudi Arabia.
Front Pediatr. 2022 Aug 16;10:891572. doi: 10.3389/fped.2022.891572. eCollection 2022.
Neonatal sepsis (NS) continues to be a critical healthcare priority for the coming decades worldwide. The aim of this study was to critically appraise the quality of recent clinical practice guidelines (CPGs) for neonatal sepsis and to summarize and compare their recommendations.
This study involves a systematic review of CPGs. We identified clinical questions and eligibility criteria and searched and screened for CPGs using bibliographic and CPG databases and professional societies. Each included CPG was assessed by four independent appraisers using the Appraisal of Guidelines for REsearch & Evaluation II (AGREE II) instrument. We summarized the recommendations in a comparison practical table. The systematic review was drafted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) statement. Its protocol was registered in the PROSPERO International Prospective Register of Systematic Reviews (ID: CRD42021258732).
Our search retrieved 4,432 citations; of which five CPGs were eligible and appraised: American Academy of Pediatrics (AAP 2018) (35 and 34 weeks); Canadian Pediatric Society (CPS 2017); National Institute for Health and Care Excellence (NICE 2021); and Queensland Maternity and Neonatal Services (QH 2020). Among these, the overall assessment of two evidence-based CPGs scored > 70% (NICE and QH), which was consistent with their higher scores in the six domains of the AGREE II instrument. In domain 3 (rigor of development), NICE and QH scored 99 and 60%, respectively. In domain 5 (applicability), they scored 96 and 74%, respectively, and in domain 6 (editorial independence), they scored 90 and 71%, respectively.
The methodological quality of the NICE CPG was superior followed by the QH CPG with relevant recommendations for use in practice.
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021258732, PROSPERO (CRD42021258732).
在全球范围内，新生儿败血症（NS）在未来几十年仍将是医疗保健的重点。本研究旨在严格评估近期新生儿败血症临床实践指南（CPG）的质量，并总结和比较其建议。
本研究涉及对CPG的系统评价。我们确定了临床问题和纳入标准，并使用书目数据库、CPG数据库和专业协会搜索和筛选CPG。每篇纳入的CPG由四名独立评估人员使用《研究与评价指南评估II》（AGREE II）工具进行评估。我们在一个比较实用表中总结了建议。系统评价根据系统评价和Meta分析的首选报告项目（PRISMA）声明起草。其方案已在PROSPERO国际前瞻性系统评价注册库中注册（ID：CRD42021258732）。
我们的检索共获得4432条引文；其中五篇CPG符合纳入标准并进行了评估：美国儿科学会（AAP 2018）（35周和34周）；加拿大儿科学会（CPS 2017）；英国国家卫生与临床优化研究所（NICE 2021）；以及昆士兰母婴服务机构（QH 2020）。其中，两篇循证CPG的总体评估得分>70%（NICE和QH），这与它们在AGREE II工具六个领域中的较高得分一致。在第3领域（制定的严谨性）中，NICE和QH的得分分别为99%和60%。在第5领域（适用性）中，它们的得分分别为96%和74%，在第6领域（编辑独立性）中，它们的得分分别为90%和71%。
NICE CPG的方法学质量最佳，其次是QH CPG，它们有相关建议可供实际应用。
https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021258732，PROSPERO（CRD42021258732）。
