南美洲的风险 HLA 等位基因和 SARS-CoV2 的潜在新表位。
Risk HLA alleles in South America and potential new epitopes for SARS-CoV2.
机构信息
Universidad San Francisco de Quito, School of Medicine, Ecuador.
出版信息
Hum Immunol. 2021 Aug;82(8):561-567. doi: 10.1016/j.humimm.2021.04.005. Epub 2021 Apr 21.
HLA alleles are associated with the body's response to infection and the regulation of the immune system. HLA alleles have been reported to be involved in response to viral infections such as SARS-CoV2. Our study reviews the HLA alleles associated with protection or susceptibility to SARS-CoV2 and the prevalence of these HLA alleles in South America. Previous studies on HLA and SARS-CoV2 infection reported that HLA-A02:02, HLA-B15:03, and HLA-C12:03 are protective; while HLA-A25:01, HLA-B46:01, and HLA-C01:02 increase susceptibility. We identified that these alleles are not frequent in South America, confirmed that the spike protein is the most immunogenic protein of SARS-CoV2, and detected new immunogenic epitopes that bound to protective HLA alleles and to HLA alleles common in South America (binding score > 0.90). These could be used as vaccine targets.
人类白细胞抗原（HLA）等位基因与机体对感染的反应和免疫系统的调节有关。已有报道称，HLA 等位基因参与了对 SARS-CoV-2 等病毒感染的反应。本研究综述了与 SARS-CoV-2 保护或易感性相关的 HLA 等位基因以及这些 HLA 等位基因在南美洲的流行情况。先前关于 HLA 和 SARS-CoV-2 感染的研究报告称，HLA-A02:02、HLA-B15:03 和 HLA-C12:03 具有保护作用；而 HLA-A25:01、HLA-B46:01 和 HLA-C01:02 则增加了易感性。我们发现这些等位基因在南美洲并不常见，证实了刺突蛋白是 SARS-CoV-2 最具免疫原性的蛋白，并检测到与保护性 HLA 等位基因和在南美洲常见的 HLA 等位基因（结合评分>0.90）结合的新免疫原性表位。这些可以作为疫苗靶点。
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