氯胺酮和可乐定对自发性高血压大鼠超声诱导肺毛细血管出血的影响。
The Influence of Xylazine and Clonidine on Lung Ultrasound-Induced Pulmonary Capillary Hemorrhage in Spontaneously Hypertensive Rats.
机构信息
Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
Department of Radiology, University of Michigan Health System, Ann Arbor, Michigan, USA.
出版信息
Ultrasound Med Biol. 2021 Aug;47(8):2331-2338. doi: 10.1016/j.ultrasmedbio.2021.03.033. Epub 2021 May 7.
Induction of pulmonary capillary hemorrhage (PCH) by lung ultrasound (LUS) depends not only on physical exposure parameters but also on physiologic conditions and drug treatment. We studied the influence of xylazine and clonidine on LUS-induced PCH in spontaneously hypertensive and normotensive rats using diagnostic B-mode ultrasound at 7.3 MHz. Using ketamine anesthesia, rats receiving saline, xylazine, or clonidine treatment were tested with different pulse peak rarefactional pressure amplitudes in 5 min exposures. Results with xylazine or clonidine in spontaneously hypertensive rats were not significantly different at the three exposure pulse peak rarefactional pressure amplitudes, and thresholds were lower (2.2 MPa) than with saline (2.6 MPa). Variations in LUS PCH were not correlated with mean systemic blood pressure. Similar to previous findings for dexmedetomidine, the clinical drug clonidine tended to increase susceptibility to LUS PCH.
肺超声（LUS）诱导的肺毛细血管出血（PCH）不仅取决于物理暴露参数，还取决于生理条件和药物治疗。我们使用 7.3 MHz 的诊断 B 型超声研究了氯胺酮和可乐定对自发性高血压和正常血压大鼠 LUS 诱导的 PCH 的影响。在接受盐水、氯胺酮或可乐定治疗的大鼠中，使用氯胺酮麻醉，在 5 分钟的暴露时间内，用不同的脉冲峰值稀疏压力幅度进行测试。在三种暴露脉冲峰值稀疏压力幅度下，自发性高血压大鼠的氯胺酮或可乐定的结果没有显著差异，阈值较低（2.2 MPa），而生理盐水的阈值较高（2.6 MPa）。LUS PCH 的变化与平均系统血压无关。与先前关于右美托咪定的发现相似，临床药物可乐定往往会增加对 LUS PCH 的易感性。
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