Foschi D, Trabucchi E, Galeone M, Ferrante F, Toti G L, Castoldi L, Musazzi M, Centemero A, Montorsi W
Institute of Biomedical Sciences, L. Sacco, University of Milan, Italy.
Int J Tissue React. 1988;10(1):53-7.
We studied the effect of a new prostaglandin analogue, 9-hydroxy-19,20-bis-norprostanoic acid (rosaprostol), on the duodenal mucosa of humans after administration of 40% ethanol. Eighteen healthy volunteers entered the study, which followed a blind cross-over design. At time 0 all the volunteers received rosaprostol or placebo; 5 minutes later, 40% ethanol (50 ml dose) was given. The mucosa was examined for lesions 3, 60 and 180 min later under endoscopy, light and scanning microscopy. It was found that: (i) 40% ethanol damaged the duodenum, with blood extravasation, inflammation and necrosis of the mucosa, (ii) rosaprostol significantly protected the mucosa 3 min after 40% ethanol, and (iii) the damage became worse after 3 h when placebo was given, whereas it was reduced after 1 h when PG was administered. The results suggest that PGs not only protect the mucosa against ethanol damage, but also stimulate its recovery.
我们研究了一种新的前列腺素类似物9-羟基-19,20-双去甲前列腺酸（罗沙前列醇）对40%乙醇给药后人体十二指肠黏膜的影响。18名健康志愿者参与了该研究，研究采用盲法交叉设计。在时间0时，所有志愿者接受罗沙前列醇或安慰剂；5分钟后，给予40%乙醇（50毫升剂量）。3、60和180分钟后在内镜检查、光学显微镜和扫描显微镜下检查黏膜病变情况。结果发现：（i）40%乙醇会损伤十二指肠，导致黏膜出血、炎症和坏死，（ii）罗沙前列醇在40%乙醇给药3分钟后能显著保护黏膜，（iii）给予安慰剂后3小时损伤加重，而给予前列腺素后1小时损伤减轻。结果表明，前列腺素不仅能保护黏膜免受乙醇损伤，还能刺激其恢复。
