Lehtola J, Pirttiaho H, Niemelä S, Sipponen P, Olsén M, Järvensivu P, Saukko P
Department of Internal Medicine, University Central Hospital, Oulu, Finland.
Ann Clin Res. 1987;19(6):391-4.
The effect of ethanol together with a meal on the mucosa of the stomach and duodenal bulb was studied in nine healthy volunteers. The pre-study gastroscopy was performed after an overnight fast. Two to four weeks later the volunteers drank 72-136 g (mean 111.2 +/- 18.3 SD) alcohol together with a meal. They underwent endoscopy again on the following morning. The endoscopic and histological changes were evaluated by scoring the lesions (0-4). Alcohol caused slight to moderate endoscopically detected changes in the stomach of seven volunteers, the difference being statistically almost significant (p congruent to 0.05) in the case of haemorrhagic lesions. In two subjects slight hyperaemia was seen in the duodenal bulb. The histological study did not reveal significant changes after alcohol drinking. The bile acid concentrations of the gastric juice did not change after drinking. It is concluded that ethanol with a meal causes only slight changes in the mucosa of the stomach, haemorrhagic ones being the most prominent.
在9名健康志愿者中研究了乙醇与食物一起对胃和十二指肠球部黏膜的影响。研究前的胃镜检查在禁食过夜后进行。两到四周后，志愿者们进食时饮用了72 - 136克（平均111.2±18.3标准差）酒精。次日早晨他们再次接受内镜检查。通过对病变进行评分（0 - 4分）来评估内镜和组织学变化。酒精导致7名志愿者的胃内出现轻度至中度的内镜下可见变化，在出血性病变方面差异几乎具有统计学意义（p约等于0.05）。在两名受试者的十二指肠球部可见轻度充血。饮酒后组织学研究未发现明显变化。饮用酒精后胃液中的胆汁酸浓度没有改变。结论是，乙醇与食物一起只会引起胃黏膜的轻微变化，其中出血性变化最为明显。
