• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin.

作者信息

Zhou Yao, Li Diyin, Luo Jianhua, Chen Aizhong, Li Xingxing, Pan Zhenrui, Wan Li, He Liuqing, Li Danyang, Li Yanyan, Dong Min, Tao Liang

机构信息

Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.

Center for Infectious Disease Research, Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, Zhejiang, China.

出版信息

Cell Res. 2021 Aug;31(8):935-938. doi: 10.1038/s41422-021-00510-z. Epub 2021 May 10.

DOI:10.1038/s41422-021-00510-z
PMID:33972749
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8107810/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8684/8324792/9cf29e28ffc7/41422_2021_510_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8684/8324792/9cf29e28ffc7/41422_2021_510_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8684/8324792/9cf29e28ffc7/41422_2021_510_Fig1_HTML.jpg

相似文献

1
Sulfated glycosaminoglycans and low-density lipoprotein receptor mediate the cellular entry of Clostridium novyi alpha-toxin.硫酸化糖胺聚糖和低密度脂蛋白受体介导诺维氏梭菌α毒素进入细胞。
Cell Res. 2021 Aug;31(8):935-938. doi: 10.1038/s41422-021-00510-z. Epub 2021 May 10.
2
LDLR, LRP1, and Megalin redundantly participate in the uptake of Clostridium novyi alpha-toxin.低密度脂蛋白受体（LDLR）、LRP1 和巨球蛋白受体（Megalin）在梭菌α毒素的摄取中冗余参与。
Commun Biol. 2022 Sep 5;5(1):906. doi: 10.1038/s42003-022-03873-0.
3
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells.硫酸化糖胺聚糖和低密度脂蛋白受体有助于艰难梭菌毒素 A 进入细胞。
Nat Microbiol. 2019 Oct;4(10):1760-1769. doi: 10.1038/s41564-019-0464-z. Epub 2019 Jun 3.
4
A PCR approach to determine the distribution of toxin genes in closely related Clostridium species: Clostridium botulinum type C and D neurotoxins and C2 toxin, and Clostridium novyi alpha toxin.一种用于确定密切相关梭菌属物种中毒素基因分布的聚合酶链反应方法：肉毒梭菌C型和D型神经毒素、C2毒素以及诺维氏梭菌α毒素。
J Med Microbiol. 2007 Feb;56(Pt 2):196-201. doi: 10.1099/jmm.0.46802-0.
5
Inositol hexakisphosphate-dependent processing of Clostridium sordellii lethal toxin and Clostridium novyi alpha-toxin.肌醇六磷酸依赖的梭菌致死毒素和诺维梭菌α毒素的加工。
J Biol Chem. 2011 Apr 29;286(17):14779-86. doi: 10.1074/jbc.M110.200691. Epub 2011 Mar 8.
6
[Phage conversion of Clostridium novyi type A (author's transl)].A型诺维氏梭菌的噬菌体转化（作者译）
Zentralbl Bakteriol A. 1980 Jun;247(1):95-100.
7
Optimization of the Production of Inactivated Clostridium novyi Type B Vaccine Using Computational Intelligence Techniques.利用计算智能技术优化B型诺维氏梭菌灭活疫苗的生产
Appl Biochem Biotechnol. 2016 Jul;179(5):895-909. doi: 10.1007/s12010-016-2038-3. Epub 2016 Mar 22.
8
Phospholipase A(2) modification of low density lipoproteins forms small high density particles with increased affinity for proteoglycans and glycosaminoglycans.磷脂酶A(2)对低密度脂蛋白的修饰形成了对蛋白聚糖和糖胺聚糖亲和力增加的小高密度颗粒。
J Biol Chem. 1999 Sep 3;274(36):25913-20. doi: 10.1074/jbc.274.36.25913.
9
The protective effect of Clostridium novyi type B alpha-toxoid against challenge with spores in guinea pigs.B型诺维氏梭菌α-类毒素对豚鼠孢子攻击的保护作用。
J Vet Med Sci. 1998 Jun;60(6):681-5. doi: 10.1292/jvms.60.681.
10
Plasmidome interchange between Clostridium botulinum, Clostridium novyi and Clostridium haemolyticum converts strains of independent lineages into distinctly different pathogens.肉毒梭菌、诺维氏梭菌和溶血性梭菌之间的质粒组交换将独立谱系的菌株转化为截然不同的病原体。
PLoS One. 2014 Sep 25;9(9):e107777. doi: 10.1371/journal.pone.0107777. eCollection 2014.

引用本文的文献

1
LDL receptor-mediated endocytosis of α-hemolysin mediates renal epithelial toxicity.低密度脂蛋白受体介导的α-溶血素内吞作用介导肾上皮毒性。
Proc Natl Acad Sci U S A. 2025 Jun 17;122(24):e2505482122. doi: 10.1073/pnas.2505482122. Epub 2025 Jun 12.
2
Characterization of heparin interactions with Clostridioides difficile toxins and its potential as anti-CDI therapeutics.肝素与艰难梭菌毒素的相互作用及其作为抗艰难梭菌感染治疗药物的潜力的表征。
Carbohydr Polym. 2025 Mar 1;351:123143. doi: 10.1016/j.carbpol.2024.123143. Epub 2024 Dec 12.
3
Bacterial toxins induce non-canonical migracytosis to aggravate acute inflammation.
细菌毒素诱导非典型迁移性细胞吞噬作用以加重急性炎症。
Cell Discov. 2024 Nov 5;10(1):112. doi: 10.1038/s41421-024-00729-1.
4
Large Clostridial Toxins: A Brief Review and Insights into Antigen Design for Veterinary Vaccine Development.大型梭菌毒素：简要综述及兽用疫苗开发抗原设计见解
Mol Biotechnol. 2024 Oct 29. doi: 10.1007/s12033-024-01303-6.
5
Sulfated glycosaminoglycans are host epithelial cell targets of the Candida albicans toxin candidalysin.硫酸化糖胺聚糖是白色念珠菌毒素白念珠菌素的宿主上皮细胞靶标。
Nat Microbiol. 2024 Oct;9(10):2553-2569. doi: 10.1038/s41564-024-01794-8. Epub 2024 Sep 16.
6
Nanomaterial-assisted oncolytic bacteria in solid tumor diagnosis and therapeutics.纳米材料辅助溶瘤细菌在实体瘤诊断与治疗中的应用
Bioeng Transl Med. 2024 Apr 17;9(4):e10672. doi: 10.1002/btm2.10672. eCollection 2024 Jul.
7
A genome-scale screen identifies sulfated glycosaminoglycans as pivotal in epithelial cell damage by .一项全基因组规模的筛选确定硫酸化糖胺聚糖是导致上皮细胞损伤的关键因素。
bioRxiv. 2024 May 23:2024.05.23.595417. doi: 10.1101/2024.05.23.595417.
8
Identification of a hemorrhagic determinant in TcdA and TcsH.鉴定 TcdA 和 TcsH 中的出血决定簇。
Microbiol Spectr. 2024 Jun 4;12(6):e0035424. doi: 10.1128/spectrum.00354-24. Epub 2024 May 6.
9
Molecular basis of TMPRSS2 recognition by Paeniclostridium sordellii hemorrhagic toxin.梭菌属 Paeniclostridium 出血毒素识别 TMPRSS2 的分子基础。
Nat Commun. 2024 Mar 4;15(1):1976. doi: 10.1038/s41467-024-46394-6.
10
An Updated View on the Cellular Uptake and Mode-of-Action of Clostridioides difficile Toxins.艰难梭菌毒素的细胞摄取和作用模式的最新研究进展
Adv Exp Med Biol. 2024;1435:219-247. doi: 10.1007/978-3-031-42108-2_11.