Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.
Nat Neurosci. 2021 Jul;24(7):907-912. doi: 10.1038/s41593-021-00850-4. Epub 2021 May 10.
Physiological need states direct decision-making toward re-establishing homeostasis. Using a two-alternative forced choice task for mice that models elements of human decisions, we found that varying hunger and thirst states caused need-inappropriate choices, such as food seeking when thirsty. These results show limits on interoceptive knowledge of hunger and thirst states to guide decision-making. Instead, need states were identified after food and water consumption by outcome evaluation, which depended on the medial prefrontal cortex.
生理需求状态直接引导决策以恢复体内平衡。我们使用一种模拟人类决策要素的小鼠二选一强制选择任务发现，饥饿和口渴状态的变化会导致不适当的需求选择，例如口渴时寻找食物。这些结果表明，对饥饿和口渴状态的内感受知识在指导决策方面存在局限性。相反，需要状态是在食物和水消耗后通过结果评估来识别的，这取决于内侧前额叶皮层。
