冠状病毒：我们应该了解病毒的哪些特征？
Coronaviruses: What Should We Know About the Characteristics of Viruses?
机构信息
Medical school, Liaocheng University, Liaocheng, China.
Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Liaocheng, China.
出版信息
Adv Exp Med Biol. 2021;1318:23-39. doi: 10.1007/978-3-030-63761-3_2.
The ongoing coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is highly contagious and fatal, posing a direct threat to human health and the global economy. Most strategies to prevent, control, and eradicate COVID-19 are established based on the specific characteristics of the pathogen. The quest for interruption and eradication of COVID-19 has moved research forward in understanding fundamental aspects of the virus genome, proteome, replication mechanisms, and virus-host interactions, which pave the way for the development of effective antiviral drugs and vaccines. This chapter provides an overview of recent progress in human coronavirus taxonomy, molecular features of the SARS-CoV-2 genome and proteome, and virus life cycle.
由严重急性呼吸系统综合症冠状病毒 2 型（SARS-CoV-2）引起的持续冠状病毒病（COVID-19）具有高度传染性和致命性，直接威胁着人类健康和全球经济。大多数预防、控制和消灭 COVID-19 的策略都是基于病原体的特定特征建立的。为了阻断和消灭 COVID-19，人们对病毒基因组、蛋白质组、复制机制和病毒-宿主相互作用的基本方面的理解进行了研究，为开发有效的抗病毒药物和疫苗铺平了道路。本章概述了人类冠状病毒分类学、SARS-CoV-2 基因组和蛋白质组的分子特征以及病毒生命周期的最新进展。
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