Issa Amalia M, Aboushawareb Sarah Ae, Eisenstat David D, Guilcher Greg Mt, Liu Geoffrey, Rassekh S Rod, Strahlendorf Caron, Tallen Gesche, Tanoshima Reo, Carleton Bruce
Personalized Precision Medicine & Targeted Therapeutics Institute, PA 19064, USA.
Departments of Pharmaceutical Sciences and Health Policy, University of The Sciences in Philadelphia, Philadelphia, PA 19104, USA.
Per Med. 2021 Jul;18(4):399-405. doi: 10.2217/pme-2020-0120. Epub 2021 May 11.
This article summarizes the background, content and outcomes of a special meeting that was convened among oncologists and scientists to discuss the role of pharmacogenetic (PGx) testing in pediatric clinical oncology practice. This meeting provided an opportunity for what the lead author (AM Issa) refers to as the 'voice of the clinician' dynamic to be amplified in order to better understand how personalized or precision medicine applications such as PGx testing are adopted and incorporated into clinical settings and what we can learn from the experiences of current and ongoing implementation PGx approaches to further the implementation of precision medicine applications in real-world environments. Group dynamics and clinical experience with PGx testing and return of results shaped the discussion.
本文总结了肿瘤学家和科学家召开的一次特别会议的背景、内容和成果，该会议旨在讨论药物遗传学（PGx）检测在儿科临床肿瘤学实践中的作用。这次会议为第一作者（AM·伊萨）所说的“临床医生的声音”这一动态提供了一个放大的机会，以便更好地了解诸如PGx检测等个性化或精准医学应用是如何被采用并纳入临床环境的，以及我们可以从当前和正在进行的PGx方法实施经验中学到什么，以进一步推动精准医学应用在现实环境中的实施。PGx检测及结果反馈的团队动态和临床经验影响了此次讨论。
