Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Department of Structural Biology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
G3 (Bethesda). 2021 Jul 14;11(7). doi: 10.1093/g3journal/jkab165.
Recent evidence indicates that the composition of the ribosome is heterogeneous and that multiple types of specialized ribosomes regulate the synthesis of specific protein subsets. In Drosophila, we find that expression of the ribosomal RpS28 protein variants RpS28a and RpS28-like preferentially occurs in the germline, a tissue resistant to aging and that it significantly declines in skeletal muscle during aging. Muscle-specific overexpression of RpS28a at levels similar to those seen in the germline decreases early mortality and promotes the synthesis of a subset of proteins with known anti-aging roles, some of which have preferential expression in the germline. These findings indicate a contribution of specialized ribosomal proteins to the regulation of the muscle proteome during aging.
最近的证据表明，核糖体的组成是不均匀的，并且多种类型的专门核糖体调节特定蛋白质亚组的合成。在果蝇中，我们发现核糖体 RpS28 蛋白变体 RpS28a 和 RpS28 样的表达优先发生在生殖系中，生殖系是一种抵抗衰老的组织，并且在衰老过程中其在骨骼肌中的表达显著下降。在类似于生殖系中所见的水平下肌肉特异性过表达 RpS28a 可降低早期死亡率并促进具有已知抗衰老作用的蛋白质亚组的合成，其中一些在生殖系中具有优先表达。这些发现表明专门核糖体蛋白在衰老过程中对肌肉蛋白质组的调节有一定的贡献。
