Department of Epidemiology, School of Medicine, Jinan University, 601 West Huangpu Road, Guangzhou, 510632, Guangdong, China.
Department of Clinical Medicine, Honghe Health Vocational College, Mengzi, China.
Qual Life Res. 2021 Sep;30(9):2467-2474. doi: 10.1007/s11136-021-02858-6. Epub 2021 May 1.
Many studies have investigated the association between handgrip strength (HGS) and depressive symptoms, but the conclusion remain controversial. We performed a meta-analysis to evaluate the longitudinal association between HGS and risk of depressive symptoms.
PubMed, PSYCINFO and EMBASE databases were searched for eligible publications up to April 2020. Pooled relative risks (RRs) with 95% confidence intervals were calculated using random-effects model. Publication bias was estimated using Egger's test and the funnel plot. Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of eligible studies.
The present meta-analysis included 8 cohort studies with 30,727 participants. Overall, higher HGS was related to a decreased risk of depressive symptoms: the pooled risk ratio (RR) of 0.74 [95% confidence intervals (CI) 0.65-0.85] with a moderate heterogeneity (I = 60.5%, P = 0.013). HGS was significantly associated with a reduced risk of depressive symptoms in males (RR = 0.69; 95% CI 0.50-0.94), but not in females.
Lower HGS was associated with an increased risk of depressive symptoms. Further studies are needed to confirm these findings and to investigate the sex differences.
许多研究调查了握力（HGS）与抑郁症状之间的关系，但结论仍存在争议。我们进行了一项荟萃分析，以评估 HGS 与抑郁症状风险之间的纵向关联。
检索 PubMed、PSYCINFO 和 EMBASE 数据库，以获取截至 2020 年 4 月的合格文献。使用随机效应模型计算合并的相对风险（RR）和 95%置信区间。使用 Egger 检验和漏斗图评估发表偏倚。使用纽卡斯尔-渥太华量表（NOS）评估合格研究的质量。
本荟萃分析纳入了 8 项队列研究，共 30727 名参与者。总体而言，较高的 HGS 与抑郁症状风险降低相关：合并的风险比（RR）为 0.74 [95%置信区间（CI）0.65-0.85]，存在中度异质性（I=60.5%，P=0.013）。HGS 与男性抑郁症状风险降低显著相关（RR=0.69；95%CI 0.50-0.94），但与女性无关。
较低的 HGS 与抑郁症状风险增加相关。需要进一步的研究来证实这些发现，并探讨性别差异。
