Department of Endocrinology, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, Jiangsu, China.
Department of Endocrinology, Shanghai Putuo District Liqun Hospital, Shanghai, 200000, China.
BMC Psychiatry. 2024 Oct 10;24(1):672. doi: 10.1186/s12888-024-06136-w.
Muscle Quality Index (MQI), defined as the muscle strength per unit of muscle mass, is considered an emerging indicator of health and physical function. This study aims to explore the relationship between MQI and the risk of depression among non-elderly US adults.
This cross-sectional study collected data from participants aged between 20 and 59 years old, utilizing the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2014. The MQI was calculated by dividing the handgrip strength (HGS, kg) by the arm and appendicular skeletal muscle mass (ASM, kg). Depression assessments were conducted using the Patient Health Questionnaire (PHQ-9). The relationship between MQI and the risk of depression was explored by weighted logistic regression, smooth curve fitting, and subgroup analyses.
A total of 4773 participants were included in this study. After adjusting for confounding factors, low MQI levels were identified as an independent risk factor for depression (OR = 0.800, 95%CI:0.668-0.957, P = 0.015). Smooth curve fitting analysis indicated a nonlinear relationship. Subgroup analysis did not identify any specific populations.
Higher MQI levels were closely associated with a lower risk of depression among non-elderly US adults. MQI could enhance our understanding of the link between muscle and depression and might serve as a simple functional measure for evaluating and predicting depression.
肌肉质量指数（MQI）定义为单位肌肉质量的肌肉力量，被认为是健康和身体功能的新兴指标。本研究旨在探讨 MQI 与美国非老年成年人抑郁风险之间的关系。
本横断面研究利用 2011 年至 2014 年的国家健康和营养调查（NHANES）数据，收集了年龄在 20 至 59 岁之间的参与者的数据。MQI 通过将握力（HGS，kg）除以手臂和四肢骨骼肌质量（ASM，kg）计算得出。使用患者健康问卷（PHQ-9）进行抑郁评估。通过加权逻辑回归、平滑曲线拟合和亚组分析探讨 MQI 与抑郁风险之间的关系。
本研究共纳入 4773 名参与者。在调整混杂因素后，低 MQI 水平被确定为抑郁的独立危险因素（OR=0.800，95%CI：0.668-0.957，P=0.015）。平滑曲线拟合分析表明存在非线性关系。亚组分析未确定任何特定人群。
较高的 MQI 水平与美国非老年成年人抑郁风险降低密切相关。MQI 可以增强我们对肌肉和抑郁之间联系的理解，并可能作为评估和预测抑郁的简单功能测量指标。
