胸部计算机断层扫描病变密度变化与 COVID-19 患者临床改善的关系。
The relationship between lesion density change in chest computed tomography and clinical improvement in COVID-19 patients.
机构信息
Department of Radiology, Istinye University, Gaziosmanpasa Medical Park Hospital, Istanbul, Turkey.
Department of Radiology, Memorial Sloan Ketteting Cancer Center, Interventional Radiology, New York, NY, USA.
出版信息
Int J Clin Pract. 2021 Sep;75(9):e14355. doi: 10.1111/ijcp.14355. Epub 2021 May 24.
OBJECTIVE
To evaluate the association of changes in chest computed tomography (CT) lesion densities with clinical improvement in COVID-19 patients.
METHODS
This was a cross-sectional analysis of hospitalised COVID-19 patients who underwent repeated chest CT. Patients who improved clinically but showed radiological progression were included. Demographic data, presentation complaints and laboratory results were retrieved from the electronic database of the hospital. Lesion density that was measured in Hounsfield units was compred between admission and discharge chest CT scans.
RESULTS
Forty patients (21 males, mean age 47.4 ± 15.1 years) were included in the analysis. The median white blood cell count and C-reactive protein significantly decreased, whereas the median lymphocyte count significantly increased at discharge compared with the admission values. The mean density significantly reduced from admission to discharge.
CONCLUSION
This is the first study in the literature reporting reduction in chest CT lesion densities correlated with clinical and laboratory improvement in COVID-19 patients.
目的
评估 COVID-19 患者胸部计算机断层扫描（CT）病变密度变化与临床改善的相关性。
方法
这是一项对住院 COVID-19 患者进行重复胸部 CT 检查的病例对照研究。纳入临床改善但影像学进展的患者。从医院的电子数据库中检索人口统计学数据、临床表现和实验室结果。比较入院和出院时 CT 扫描的病变密度（以亨氏单位测量）。
结果
共纳入 40 例患者（21 例男性，平均年龄 47.4 ± 15.1 岁）。与入院值相比，出院时白细胞计数和 C 反应蛋白中位数显著降低，而淋巴细胞计数中位数显著升高。平均密度从入院到出院显著降低。
结论
这是文献中首次报道 COVID-19 患者胸部 CT 病变密度与临床和实验室改善相关的研究。
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