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细胞在硅-羟基磷灰石同轴复合材料上的行为。

Cell behavior on silica-hydroxyapatite coaxial composite.

机构信息

Instituto de Ciencias Biomédicas, Universidad Autónoma de Ciudad Juárez, Ciudad Juárez, Chihuahua, México.

Departamento de Estudios de Posgrado e Investigación, Tecnológico Nacional de México campus Ciudad Juárez, Ciudad Juárez, Chihuahua, México.

出版信息

PLoS One. 2021 May 11;16(5):e0246256. doi: 10.1371/journal.pone.0246256. eCollection 2021.

DOI:10.1371/journal.pone.0246256
PMID:33974626
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8112647/
Abstract

Progress in the manufacture of scaffolds in tissue engineering lies in the successful combination of materials such as bioceramics having properties as porosity, biocompatibility, water retention, protein adsorption, mechanical strength and biomineralization. Hydroxyapatite (HA) is a ceramic material with lots of potential in tissue regeneration, however, its structural characteristics need to be improved for better performance. In this study, silica-hydroxyapatite (SiO2-HA) non-woven ceramic electrospunned membranes were prepared through the sol-gel method. Infrared spectra, scanning electron microscopy and XRD confirmed the structure and composition of composite. The obtained SiO2-HA polymeric fibers had approximately 230±20 nm in diameter and were then sintered at 800°C average diameter decreased to 110±17 nm. Three configurations of the membranes were obtained and tested in vitro, showing that the composite of SiO2-HA fibers showed a high percentage of viability on a fibroblast cell line. It is concluded that the fibers of SiO2-HA set in a coaxial configuration may be helpful to develop materials for bone regeneration.

摘要

组织工程中支架的制造进展在于成功结合了具有多孔性、生物相容性、保水性、蛋白质吸附性、机械强度和生物矿化性等特性的生物陶瓷材料，如羟基磷灰石（HA）。HA 是一种在组织再生方面具有巨大潜力的陶瓷材料，然而，其结构特性需要改进以提高性能。在本研究中，通过溶胶-凝胶法制备了硅酸钠-羟基磷灰石（SiO2-HA）非织造陶瓷静电纺丝膜。红外光谱、扫描电子显微镜和 XRD 证实了复合材料的结构和组成。得到的 SiO2-HA 聚合物纤维直径约为 230±20nm，然后在 800°C 下烧结，平均直径减小至 110±17nm。获得了三种膜结构并进行了体外测试，结果表明 SiO2-HA 纤维复合材料对成纤维细胞系具有高存活率。研究结论认为，同轴配置的 SiO2-HA 纤维可能有助于开发用于骨再生的材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/d0f50a973e0b/pone.0246256.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/e402943e743e/pone.0246256.g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/4b632651a569/pone.0246256.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/a86db66cf1ba/pone.0246256.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/b7f381e23355/pone.0246256.g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/7a304cf9bd9c/pone.0246256.g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/d0f50a973e0b/pone.0246256.g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/e402943e743e/pone.0246256.g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/40be630e03eb/pone.0246256.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/c7c453001173/pone.0246256.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/4b632651a569/pone.0246256.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/a86db66cf1ba/pone.0246256.g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a750/8112647/d0f50a973e0b/pone.0246256.g010.jpg

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