Health Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Department of Nutrition and Food Hygiene, Faculty of Health, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Phytother Res. 2021 Aug;35(8):4433-4441. doi: 10.1002/ptr.7146. Epub 2021 May 11.
The prevalence of metabolic syndrome (MetS) is increasing. It is closely linked to nonalcoholic fatty liver disease. Garlic consumption as a strategy for the management of MetS has been suggested. We investigated the effect of garlic supplementation on MetS components, insulin resistance, fatty liver index (FLI), and appetite in subjects with MetS. Ninety subjects were assigned to receive 1,600 mg/d garlic powder or placebo for 3 months. The primary outcomes included MetS components. The secondary outcomes included insulin resistance, FLI, and appetite. Garlic supplementation compared with the placebo led to a significant increase in high density lipoprotein-cholesterol (4.5 vs. -1.8, p < .001) and a significant reduction in waist circumference (-1.3 vs. 0.0, p = .001), diastolic blood pressure (-6.7 vs. 0.0, p < .001), systolic blood pressure (-7.7 vs. 0.5, p < .001), triglyceride (-40.0 vs. 0.1, p < .001), γ-glutamyl transferase (-3.2 vs. 0.6, p = .01), FLI (-5.5 vs. 0.1, p < .001), insulin (-2.9 vs. -1.1, p < .001), homeostatic model of assessment for insulin resistance (-0.5 vs. -0.3, p < .001) and appetite (hunger: -11.7 vs. 1.7, p < .001; fullness: 10.0 vs. 0.3, p = .001; desire to eat: -6.7 vs. 2.1, p < .001; and ability to eat: -11.5 vs. -1.0, p < .001). Garlic improves MetS components, insulin resistance, FLI, and appetite.
代谢综合征（MetS）的患病率正在上升。它与非酒精性脂肪肝密切相关。大蒜的摄入被认为是管理 MetS 的一种策略。我们研究了大蒜补充剂对 MetS 患者的 MetS 成分、胰岛素抵抗、脂肪肝指数（FLI）和食欲的影响。90 名受试者被分配接受 1600mg/d 大蒜粉或安慰剂治疗 3 个月。主要结局包括 MetS 成分。次要结局包括胰岛素抵抗、FLI 和食欲。与安慰剂相比，大蒜补充剂可显著增加高密度脂蛋白胆固醇（4.5 对-1.8，p < 0.001），显著减少腰围（-1.3 对 0.0，p = 0.001）、舒张压（-6.7 对 0.0，p < 0.001）、收缩压（-7.7 对 0.5，p < 0.001）、甘油三酯（-40.0 对 0.1，p < 0.001）、γ-谷氨酰转移酶（-3.2 对 0.6，p = 0.01）、FLI（-5.5 对 0.1，p < 0.001）、胰岛素（-2.9 对-1.1，p < 0.001）、胰岛素抵抗评估的稳态模型（-0.5 对-0.3，p < 0.001）和食欲（饥饿：-11.7 对 1.7，p < 0.001；饱腹感：10.0 对 0.3，p = 0.001；进食欲望：-6.7 对 2.1，p < 0.001；进食能力：-11.5 对-1.0，p < 0.001）。大蒜可改善 MetS 成分、胰岛素抵抗、FLI 和食欲。
