Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
Gastroenterology and Hepatology Subdivision of Internal Medicine, Imam Khomeini Hospital, School of Medicine, Urmia University of Medical Sciences, Urmia, Iran.
Complement Ther Med. 2020 Jun;51:102428. doi: 10.1016/j.ctim.2020.102428. Epub 2020 May 11.
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Insulin resistance, oxidative stress, and obesity are major contributors to NAFLD pathogenesis. The effects of garlic powder supplementation on these risk factors in patients with NAFLD was investigated.
In this 12-wk, randomized controlled clinical trial, ninety patients with NAFLD were randomly assigned to two groups. The treatment group received four tablets of garlic (each coated tablet contained 400 mg garlic powder) daily and the control group received four tablets of placebo (each coated tablet contained 400 mg starch).
A significant decrease was seen in the treatment group compared to the control group in waist circumference (P = 0.001), body fat percent (P < 0.001), serum concentration of fasting blood sugar (P = 0.01), insulin (P < 0.001), homeostatic model assessment for insulin resistance (P < 0.001), and malondialdehyde (P < 0.001), as well as significant increase in skeletal muscle mass (P = 0.002), serum concentration of superoxide dismutase (P < 0.001), and total antioxidant capacity (P < 0.001).
Garlic powder supplementation improved risk factors of NAFLD. Further studies are needed to determine the effects of garlic on hepatic features in patients with NAFLD. The study protocol was registered at Iranian clinical trials website under code IRCT20170206032417N4.
非酒精性脂肪性肝病（NAFLD）是全球最常见的慢性肝病。胰岛素抵抗、氧化应激和肥胖是 NAFLD 发病机制的主要因素。本研究旨在探讨大蒜粉补充剂对 NAFLD 患者这些危险因素的影响。
在这项为期 12 周的随机对照临床试验中，90 名 NAFLD 患者被随机分为两组。治疗组每天服用 4 片大蒜（每片包衣片含 400mg 大蒜粉），对照组服用 4 片安慰剂（每片包衣片含 400mg 淀粉）。
与对照组相比，治疗组腰围（P=0.001）、体脂百分比（P<0.001）、空腹血糖血清浓度（P=0.01）、胰岛素（P<0.001）、胰岛素抵抗稳态模型评估（P<0.001）和丙二醛（P<0.001）显著降低，骨骼肌质量（P=0.002）、超氧化物歧化酶（P<0.001）和总抗氧化能力（P<0.001）血清浓度显著升高。
大蒜粉补充剂改善了 NAFLD 的危险因素。需要进一步研究确定大蒜对 NAFLD 患者肝特征的影响。该研究方案已在伊朗临床试验网站注册，注册号为 IRCT20170206032417N4。
