评估组织基础检测在自身免疫性脑炎诊断算法中的作用。
Assessing the role of a tissue-based assay in the diagnostic algorithm of autoimmune encephalitis.
机构信息
Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy; UOC Neurologia, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
出版信息
J Neuroimmunol. 2021 Jul 15;356:577601. doi: 10.1016/j.jneuroim.2021.577601. Epub 2021 Apr 30.
Tissue-based assay (TBA) is a widely-used method to detect neural autoantibodies, but the diagnostic accuracy for autoimmune encephalitis (AE) has not yet been adequately measured. We retrospectively evaluated the sensitivity and specificity of an indirect immunofluorescence TBA (IIF-TBA) in 159 patients with suspected AE. Serum and cerebrospinal fluid (CSF) specimens were collected and tested from December 2012 to September 2020. In the paired sample analysis, serum testing showed higher sensitivity than CSF, while the latter had higher specificity. Based on these results, we clarify the advantages of using a TBA as the principal screening method for patients with suspected AE.
基于组织的检测（TBA）是一种广泛用于检测神经自身抗体的方法，但对于自身免疫性脑炎（AE）的诊断准确性尚未得到充分评估。我们回顾性评估了间接免疫荧光 TBA（IIF-TBA）在 159 例疑似 AE 患者中的敏感性和特异性。血清和脑脊液（CSF）标本于 2012 年 12 月至 2020 年 9 月采集和检测。在配对样本分析中，血清检测的敏感性高于 CSF，而后者的特异性更高。基于这些结果，我们阐明了 TBA 作为疑似 AE 患者主要筛查方法的优势。
Zotero 插件