Businello Gianluca, Galuppini Francesca, Fassan Matteo
Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Department of Medicine (DIMED), Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Best Pract Res Clin Gastroenterol. 2021 Mar-Apr;50-51:101730. doi: 10.1016/j.bpg.2021.101730. Epub 2021 Feb 15.
The phenotypical and molecular heterogeneity of gastric cancer has hampered the introduction in clinical practice of a unifying classification of the disease. However, as next generation sequencing (NGS) technologies enhanced the comprehension of the molecular landscape of gastric cancer, novel molecular classification systems have been proposed, allowing the dissection of molecular tumor heterogeneity and paving the way for the development of new targeted therapies. Moreover, the use of NGS analyses in the molecular profiling of formalin-fixed paraffin-embedded (FFPE) specimens will improve patient selection for the enrolment in novel clinical trials. In conclusion, the application of NGS in precision oncology will revolutionize the diagnosis and clinical management in gastric cancer patients.
胃癌的表型和分子异质性阻碍了统一疾病分类在临床实践中的引入。然而，随着下一代测序（NGS）技术加深了对胃癌分子格局的理解，新的分子分类系统被提出，这有助于剖析分子肿瘤异质性，并为新的靶向治疗的发展铺平道路。此外，在福尔马林固定石蜡包埋（FFPE）标本的分子谱分析中使用NGS分析将改善患者入选新型临床试验的选择。总之，NGS在精准肿瘤学中的应用将彻底改变胃癌患者的诊断和临床管理。
