Department of Surgery, Yale University, School of Medicine, PO Box 208062, New Haven, CT 06520, USA.
Department of Surgery, Yale University, School of Medicine, PO Box 208062, New Haven, CT 06520, USA.
Surg Clin North Am. 2019 Jun;99(3):511-527. doi: 10.1016/j.suc.2019.02.005. Epub 2019 Mar 28.
Next-generation sequencing has enabled genome-wide molecular profiling of gastric and esophageal malignancies at single-nucleotide resolution. The resultant genomic profiles provide information about the specific oncogenic pathways that are the likely driving forces behind tumorigenesis and progression. The abundance of available genomic data has immense potential to redefine management paradigms for these difficult disease processes. The ability to capitalize on the information provided through high-throughput sequencing technologies will define cancer care in the coming decades and could shift the paradigm from current stage-based, organ-specific treatments toward tailored regimens that target the specific culprit pathways driving individual tumors.
下一代测序技术使得能够以单核苷酸分辨率对胃和食管恶性肿瘤进行全基因组分子谱分析。所得的基因组谱提供了有关特定致癌途径的信息，这些途径可能是肿瘤发生和进展的主要驱动力。大量可用的基因组数据具有巨大的潜力，可以重新定义这些困难疾病过程的管理模式。利用高通量测序技术提供的信息的能力将定义未来几十年的癌症治疗，并可能将当前基于阶段的、针对特定器官的治疗模式转变为针对驱动个体肿瘤的特定罪魁祸首途径的靶向治疗方案。
