奥氮平的治疗药物监测：临床相关的简便可靠方法。
Therapeutic drug monitoring of olanzapine: Easy and reliable method for clinical correlation.
机构信息
Department of Clinical Pharmacy and Pharm. D, Vaagdevi College of Pharmacy, Kakatiya University, MGM Hospital, Warangal, Telangana, India.
Department of Psychiatry, Kakatiya Medical College, MGM Hospital, Warangal, Telangana, India.
出版信息
Indian J Pharmacol. 2021 Jan-Feb;53(1):2-5. doi: 10.4103/ijp.IJP_114_20.
AIM
The current work establishes an easy, reliable technique for the estimation of serum Olanzapine concentration which correlates it clinically.
SUBJECTS AND METHODS
The work was agreed in 61 schizophrenic patients who were on olanzapine. Serum drug amount was estimated by normal-phase high-performance liquid chromatography and brief psychiatry rating scale was used to determine disease progression.
RESULTS
Samples provided 61 patients, 40 were under sub-therapeutic range, 18 were under therapeutic range and 3 were above the therapeutic range.
CONCLUSION
Therapeutic drug monitoring must be a part of clinical practice in psychiatric hospitals for optimizing the dose of an individual patient along with the correlation of serum concentration with the clinical assessment scales.
目的
本研究旨在建立一种简单、可靠的奥氮平血清浓度估算方法，并将其与临床相关联。
受试者和方法
本研究纳入了 61 名正在服用奥氮平的精神分裂症患者。采用正相高效液相色谱法测定血清药物浓度，使用简明精神病评定量表评估疾病进展。
结果
共采集了 61 例患者的样本，其中 40 例处于亚治疗范围，18 例处于治疗范围，3 例处于治疗范围以上。
结论
治疗药物监测必须成为精神病院临床实践的一部分，以优化个体患者的剂量，并将血清浓度与临床评估量表相关联。
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