Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil.
World Mosquito Program, Fiocruz, Rio de Janeiro, RJ, Brazil.
Sci Rep. 2021 May 11;11(1):10039. doi: 10.1038/s41598-021-89409-8.
Field release of Wolbachia-infected Aedes aegypti has emerged as a promising solution to manage the transmission of dengue, Zika and chikungunya in endemic areas across the globe. Through an efficient self-dispersing mechanism, and the ability to induce virus-blocking properties, Wolbachia offers an unmatched potential to gradually modify wild Ae. aegypti populations turning them unsuitable disease vectors. Here we describe a proof-of-concept field trial carried out in a small community of Niterói, greater Rio de Janeiro, Brazil. Following the release of Wolbachia-infected eggs, we report here a successful invasion and long-term establishment of the bacterium across the territory, as denoted by stable high-infection indexes (> 80%). We have also demonstrated that refractoriness to dengue and Zika viruses, either thorough oral-feeding or intra-thoracic saliva challenging assays, was maintained over the adaptation to the natural environment of Southeastern Brazil. These findings further support Wolbachia's ability to invade local Ae. aegypti populations and impair disease transmission, and will pave the way for future epidemiological and economic impact assessments.
现场释放携带沃尔巴克氏体的埃及伊蚊已成为一种有前途的解决方案，可用于控制全球流行地区登革热、寨卡和基孔肯雅热的传播。通过有效的自我扩散机制和诱导病毒阻断特性，沃尔巴克氏体具有无与伦比的潜力，可以逐渐改变野生埃及伊蚊种群，使其不再适合作为疾病传播媒介。本文描述了在巴西里约热内卢州尼泰罗伊的一个小社区进行的一项概念验证现场试验。在释放携带沃尔巴克氏体的卵后，我们报告了该细菌在整个地区成功入侵和长期建立，其特征是稳定的高感染指数（>80%）。我们还证明了对登革热和寨卡病毒的抗药性，无论是通过口服喂养还是胸内唾液挑战试验，在适应巴西东南部的自然环境过程中得以维持。这些发现进一步支持了沃尔巴克氏体入侵当地埃及伊蚊种群并削弱疾病传播的能力，并将为未来的流行病学和经济影响评估铺平道路。
