Ayisi-Boateng Nana K, Owusu Michael, Tawiah Phyllis, Ampah Brenda A, Sylverken Augustina A, Wusu-Ansah Osei K, Sarfo Fred S, Phillips Richard O
Department of Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
University Hospital, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Ghana Med J. 2020 Dec;54(4 Suppl):39-45. doi: 10.4314/gmj.v54i4s.7.
In high-income countries, mortality related to hospitalized patients with the Coronavirus disease 2019 (COVID-19) is approximately 4-5%. However, data on COVID-19 admissions from sub-Saharan Africa are scanty.
To describe the clinical profile and determinants of outcomes of patients with confirmed COVID-19 admitted at a hospital in Ghana.
A prospective study involving 25 patients with real time polymerase chain reaction confirmed COVID-19 admitted to the treatment centre of the University Hospital, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana from 1 June to 27 July, 2020. They were managed and followed up for outcomes. Data were analysed descriptively, and predictors of mortality assessed using a multivariate logistic regression modelling.
The mean age of the patients was 59.3 ± 20.6 years, and 14 (56%) were males. The main symptoms at presentation were breathlessness (68%) followed by fever (56%). The cases were categorized as mild (6), moderate (6), severe (10) and critical (3). Hypertension was the commonest comorbidity present in 72% of patients. Medications used in patient management included dexamethasone (68%), azithromycin (96%), and hydroxychloroquine (4%). Five of 25 cases died (Case fatality ratio 20%). Increasing age and high systolic blood pressure were associated with mortality.
Case fatality in this sample of hospitalized COVID-19 patients was high. Thorough clinical assessment, severity stratification, aggressive management of underlying co-morbidities and standardized protocols incountry might improve outcomes.
None declared.
在高收入国家，2019年冠状病毒病（COVID-19）住院患者的死亡率约为4%-5%。然而，撒哈拉以南非洲地区COVID-19入院患者的数据却很匮乏。
描述在加纳一家医院确诊的COVID-19患者的临床特征及预后的决定因素。
一项前瞻性研究，纳入了2020年6月1日至7月27日在加纳库马西夸梅·恩克鲁玛科技大学（KNUST）大学医院治疗中心收治的25例经实时聚合酶链反应确诊为COVID-19的患者。对他们进行管理并随访预后情况。对数据进行描述性分析，并使用多变量逻辑回归模型评估死亡率的预测因素。
患者的平均年龄为59.3±20.6岁，其中14例（56%）为男性。就诊时的主要症状为呼吸困难（68%），其次是发热（56%）。病例分为轻症（6例）、中症（6例）、重症（10例）和危重症（3例）。高血压是最常见的合并症，72%的患者患有该疾病。患者管理中使用的药物包括地塞米松（68%）、阿奇霉素（96%）和羟氯喹（4%）。25例中有5例死亡（病死率20%）。年龄增长和收缩压升高与死亡率相关。
该组住院COVID-19患者的病死率较高。全面的临床评估、严重程度分层、积极治疗基础合并症以及国内标准化方案可能会改善预后。
未声明。
