Hardy Yasmine O, Amenuke Divine A, Hutton-Mensah Kojo A, Chadwick David R, Larsen-Reindorf Rita
Department of Medicine, Komfo Anokye Teaching Hospital/School of Medical Sciences, Kwame Nkrumah University of Science & Technology, Kumasi, Ghana.
Department of Medicine, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Ghana Med J. 2020 Dec;54(4 Suppl):121-124. doi: 10.4314/gmj.v54i4s.20.
Coronavirus disease 2019 (COVID-19) is especially severe in patients with underlying chronic conditions, with increased risk of mortality. There is concern that people living with HIV (PLWH), especially those with severe immunosuppression, and COVID-19 may have severe disease and a negative clinical outcome. Most studies on COVID-19 in PLWH are from Asia, Europe and America where population dynamics, antiretroviral treatment coverage and coexisting opportunistic infections may differ from that in sub-Saharan Africa. We report on the clinical profile and outcome of three cases of PLWH co-infected with SARS-CoV-2. They all presented with fever, cough and breathlessness and also had advanced HIV infection as evidenced by opportunistic infections, high HIV viral loads and low CD4 counts. The patients responded favourably to the standard of care and were discharged home. Our findings suggest that PLWH with advanced immunosuppression may not necessarily have an unfavourable disease course and outcome. However, case-controlled studies with a larger population size are needed to better understand the impact of COVID-19 in this patient population.
Not declared.
2019冠状病毒病（COVID-19）在患有基础慢性病的患者中尤为严重，死亡风险增加。人们担心，感染艾滋病毒的人（PLWH），尤其是那些免疫严重抑制的人，感染COVID-19后可能会患上严重疾病并出现不良临床结局。大多数关于PLWH感染COVID-19的研究来自亚洲、欧洲和美洲，这些地区的人口动态、抗逆转录病毒治疗覆盖率和并存的机会性感染情况可能与撒哈拉以南非洲不同。我们报告了3例合并感染SARS-CoV-2的PLWH的临床特征和结局。他们均表现为发热、咳嗽和呼吸急促，并且存在机会性感染、高HIV病毒载量和低CD4细胞计数，证明患有晚期HIV感染。患者对标准治疗反应良好，已出院回家。我们的研究结果表明，免疫严重抑制的PLWH不一定会有不良的病程和结局。然而，需要开展更大规模的病例对照研究，以更好地了解COVID-19对该患者群体的影响。
未申报。
